The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex

Understanding the molecular pathways disrupted in motor neuron diseases is urgently needed. Here, we employed CRISPR knockout (KO) to investigate the functions of four ALS-causative RNA/DNA binding proteins (FUS, EWSR1, TAF15 and MATR3) within the RNAP II/U1 snRNP machinery. We found that each of th...

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Detalles Bibliográficos
Autores principales: Chi, Binkai, O’Connell, Jeremy D, Iocolano, Alexander D, Coady, Jordan A, Yu, Yong, Gangopadhyay, Jaya, Gygi, Steven P, Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294556/
https://www.ncbi.nlm.nih.gov/pubmed/30398641
http://dx.doi.org/10.1093/nar/gky1093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294556/
https://www.ncbi.nlm.nih.gov/pubmed/30398641
http://dx.doi.org/10.1093/nar/gky1093

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