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Transcriptional Regulation of the Huntingtin Gene

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). This review examines the known mechanisms of HTT gene regulation. We discuss HTT e...

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Detalles Bibliográficos
Autores principales:	Thomson, Sarah B., Leavitt, Blair R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294578/ https://www.ncbi.nlm.nih.gov/pubmed/30452421 http://dx.doi.org/10.3233/JHD-180331

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