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The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis

In the present study, we included currently published evidence to comprehensively evaluate the influence of the rs5498 polymorphism within the ICAM1 (intercellular adhesion molecule 1) gene on the genetic risk of multiple sclerosis. STATA 12.0 software was utilized to carry out the heterogeneity ass...

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Detalles Bibliográficos
Autores principales: Jiang, Chuan, Xie, Chunli, Feng, Jianli, Hao, Maolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294617/
https://www.ncbi.nlm.nih.gov/pubmed/30473535
http://dx.doi.org/10.1042/BSR20181642
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author Jiang, Chuan
Xie, Chunli
Feng, Jianli
Hao, Maolin
author_facet Jiang, Chuan
Xie, Chunli
Feng, Jianli
Hao, Maolin
author_sort Jiang, Chuan
collection PubMed
description In the present study, we included currently published evidence to comprehensively evaluate the influence of the rs5498 polymorphism within the ICAM1 (intercellular adhesion molecule 1) gene on the genetic risk of multiple sclerosis. STATA 12.0 software was utilized to carry out the heterogeneity assessment, association test, and Begg’s test as well as the Egger’s tests and sensitivity analyses. A total of 11 high-quality case–control studies were selected from the initially retrieved 2209 articles. The lack of high heterogeneity led to the use of a fixed-effect model in all genetic models. The results of the association test showed a reduced risk of multiple sclerosis in the allelic G vs A (P(association) = 0.036, OR = 0.91) and dominant AG+GG vs AA (P(association) = 0.042, OR = 0.85) but not in other genetic models (all P(association) > 0.05). In addition, the negative results were observed in further subgroup analyses based on ethnicity or Hardy-Weinberg equilibrium in all genetic models. Data from Begg’s and Egger’s tests further excluded the presence of remarkable publication bias, while sensitivity analysis data supported stable outcomes. Thus, we conclude that ICAM1 rs5498 may not be related to the risk of multiple sclerosis in Caucasian or Asian populations, which still merits further research.
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spelling pubmed-62946172018-12-27 The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis Jiang, Chuan Xie, Chunli Feng, Jianli Hao, Maolin Biosci Rep Research Articles In the present study, we included currently published evidence to comprehensively evaluate the influence of the rs5498 polymorphism within the ICAM1 (intercellular adhesion molecule 1) gene on the genetic risk of multiple sclerosis. STATA 12.0 software was utilized to carry out the heterogeneity assessment, association test, and Begg’s test as well as the Egger’s tests and sensitivity analyses. A total of 11 high-quality case–control studies were selected from the initially retrieved 2209 articles. The lack of high heterogeneity led to the use of a fixed-effect model in all genetic models. The results of the association test showed a reduced risk of multiple sclerosis in the allelic G vs A (P(association) = 0.036, OR = 0.91) and dominant AG+GG vs AA (P(association) = 0.042, OR = 0.85) but not in other genetic models (all P(association) > 0.05). In addition, the negative results were observed in further subgroup analyses based on ethnicity or Hardy-Weinberg equilibrium in all genetic models. Data from Begg’s and Egger’s tests further excluded the presence of remarkable publication bias, while sensitivity analysis data supported stable outcomes. Thus, we conclude that ICAM1 rs5498 may not be related to the risk of multiple sclerosis in Caucasian or Asian populations, which still merits further research. Portland Press Ltd. 2018-12-11 /pmc/articles/PMC6294617/ /pubmed/30473535 http://dx.doi.org/10.1042/BSR20181642 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Jiang, Chuan
Xie, Chunli
Feng, Jianli
Hao, Maolin
The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title_full The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title_fullStr The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title_full_unstemmed The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title_short The genetic effect of the ICAM1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
title_sort genetic effect of the icam1 (intercellular adhesion molecule 1) rs5498 polymorphism on the susceptibility towards multiple sclerosis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294617/
https://www.ncbi.nlm.nih.gov/pubmed/30473535
http://dx.doi.org/10.1042/BSR20181642
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