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Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer

Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A litera...

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Autores principales: Yang, Yun, Liu, Rongxun, Ren, Feng, Guo, Rui, Zhang, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294633/
https://www.ncbi.nlm.nih.gov/pubmed/30446526
http://dx.doi.org/10.1042/BSR20181550
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author Yang, Yun
Liu, Rongxun
Ren, Feng
Guo, Rui
Zhang, Pengfei
author_facet Yang, Yun
Liu, Rongxun
Ren, Feng
Guo, Rui
Zhang, Pengfei
author_sort Yang, Yun
collection PubMed
description Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. Results: A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS (n=10, HR = 1.73, 95% confidence interval [CI] = 1.44–2.07, P<0.001). Similar results were observed for overall survival (OS) (n=9, HR = 1.61, 95% CI = 1.39–1.86, P<0.001). Moreover, a high NLR was also correlated with lymph node metastasis (n=7, odds ratio [OR] = 1.62, 95% CI = 1.32–1.98, P<0.001), advanced tumor stage (n=7, OR = 2.63, 95% CI = 2.12–3.25, P<0.001), T stage (n=6, OR = 3.22, 95% CI = 2.59–4.01, P<0.001), tumor differentiation (n=5, OR = 1.48, 95% CI = 1.03–2.11, P=0.033), and perineural invasion (n=4, OR = 1.83, 95% CI = 1.4–2.39, P<0.001). However, an elevated NLR was not correlated with gender. Conclusion: This meta-analysis showed that the NLR might be a potential independent prognostic factor in patients with oral cancer.
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spelling pubmed-62946332018-12-27 Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer Yang, Yun Liu, Rongxun Ren, Feng Guo, Rui Zhang, Pengfei Biosci Rep Research Articles Objectives: Many studies have examined the prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in oral cancer; however, the results are contradictory. We, therefore, conducted a meta-analysis aiming to clarify the prognostic value of the NLR in oral cancer patients. Methods: A literature search was conducted in the PubMed, Web of Science, and Embase databases. Stata version 12.0 was used for statistical analysis. Results: A total of 14 studies with 3216 patients were finally included. The results indicated that a high NLR was significantly associated with worse DFS (n=10, HR = 1.73, 95% confidence interval [CI] = 1.44–2.07, P<0.001). Similar results were observed for overall survival (OS) (n=9, HR = 1.61, 95% CI = 1.39–1.86, P<0.001). Moreover, a high NLR was also correlated with lymph node metastasis (n=7, odds ratio [OR] = 1.62, 95% CI = 1.32–1.98, P<0.001), advanced tumor stage (n=7, OR = 2.63, 95% CI = 2.12–3.25, P<0.001), T stage (n=6, OR = 3.22, 95% CI = 2.59–4.01, P<0.001), tumor differentiation (n=5, OR = 1.48, 95% CI = 1.03–2.11, P=0.033), and perineural invasion (n=4, OR = 1.83, 95% CI = 1.4–2.39, P<0.001). However, an elevated NLR was not correlated with gender. Conclusion: This meta-analysis showed that the NLR might be a potential independent prognostic factor in patients with oral cancer. Portland Press Ltd. 2018-12-11 /pmc/articles/PMC6294633/ /pubmed/30446526 http://dx.doi.org/10.1042/BSR20181550 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Yang, Yun
Liu, Rongxun
Ren, Feng
Guo, Rui
Zhang, Pengfei
Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title_full Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title_fullStr Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title_full_unstemmed Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title_short Prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
title_sort prognostic and clinicopathological significance of neutrophil-to-lymphocyte ratio in patients with oral cancer
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294633/
https://www.ncbi.nlm.nih.gov/pubmed/30446526
http://dx.doi.org/10.1042/BSR20181550
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