Cargando…
Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease
Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson’s disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years....
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294819/ https://www.ncbi.nlm.nih.gov/pubmed/30595758 http://dx.doi.org/10.1007/s12559-018-9575-8 |
_version_ | 1783380793560662016 |
---|---|
author | Mekyska, Jiri Galaz, Zoltan Kiska, Tomas Zvoncak, Vojtech Mucha, Jan Smekal, Zdenek Eliasova, Ilona Kostalova, Milena Mrackova, Martina Fiedorova, Dagmar Faundez-Zanuy, Marcos Solé-Casals, Jordi Gomez-Vilda, Pedro Rektorova, Irena |
author_facet | Mekyska, Jiri Galaz, Zoltan Kiska, Tomas Zvoncak, Vojtech Mucha, Jan Smekal, Zdenek Eliasova, Ilona Kostalova, Milena Mrackova, Martina Fiedorova, Dagmar Faundez-Zanuy, Marcos Solé-Casals, Jordi Gomez-Vilda, Pedro Rektorova, Irena |
author_sort | Mekyska, Jiri |
collection | PubMed |
description | Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson’s disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years. The aim of this study is to employ a complex quantitative analysis of the phonation, articulation and prosody in PD patients in order to identify the relationship between HD and FOG, and establish a mathematical model that would predict FOG deficits using acoustic analysis at baseline. We enrolled 75 PD patients who were assessed by 6 clinical scales including the Freezing of Gait Questionnaire (FOG–Q). We subsequently extracted 19 acoustic measures quantifying speech disorders in the fields of phonation, articulation and prosody. To identify the relationship between HD and FOG, we performed a partial correlation analysis. Finally, based on the selected acoustic measures, we trained regression models to predict the change in FOG during a 2-year follow-up. We identified significant correlations between FOG–Q scores and the acoustic measures based on formant frequencies (quantifying the movement of the tongue and jaw) and speech rate. Using the regression models, we were able to predict a change in particular FOG–Q scores with an error of between 7.4 and 17.0 %. This study is suggesting that FOG in patients with PD is mainly linked to improper articulation, a disturbed speech rate and to intelligibility. We have also proved that the acoustic analysis of HD at the baseline can be used as a predictor of the FOG deficit during 2 years of follow-up. This knowledge enables researchers to introduce new cognitive systems that predict gait difficulties in PD patients. |
format | Online Article Text |
id | pubmed-6294819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-62948192018-12-28 Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease Mekyska, Jiri Galaz, Zoltan Kiska, Tomas Zvoncak, Vojtech Mucha, Jan Smekal, Zdenek Eliasova, Ilona Kostalova, Milena Mrackova, Martina Fiedorova, Dagmar Faundez-Zanuy, Marcos Solé-Casals, Jordi Gomez-Vilda, Pedro Rektorova, Irena Cognit Comput Article Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson’s disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years. The aim of this study is to employ a complex quantitative analysis of the phonation, articulation and prosody in PD patients in order to identify the relationship between HD and FOG, and establish a mathematical model that would predict FOG deficits using acoustic analysis at baseline. We enrolled 75 PD patients who were assessed by 6 clinical scales including the Freezing of Gait Questionnaire (FOG–Q). We subsequently extracted 19 acoustic measures quantifying speech disorders in the fields of phonation, articulation and prosody. To identify the relationship between HD and FOG, we performed a partial correlation analysis. Finally, based on the selected acoustic measures, we trained regression models to predict the change in FOG during a 2-year follow-up. We identified significant correlations between FOG–Q scores and the acoustic measures based on formant frequencies (quantifying the movement of the tongue and jaw) and speech rate. Using the regression models, we were able to predict a change in particular FOG–Q scores with an error of between 7.4 and 17.0 %. This study is suggesting that FOG in patients with PD is mainly linked to improper articulation, a disturbed speech rate and to intelligibility. We have also proved that the acoustic analysis of HD at the baseline can be used as a predictor of the FOG deficit during 2 years of follow-up. This knowledge enables researchers to introduce new cognitive systems that predict gait difficulties in PD patients. Springer US 2018-06-27 2018 /pmc/articles/PMC6294819/ /pubmed/30595758 http://dx.doi.org/10.1007/s12559-018-9575-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Mekyska, Jiri Galaz, Zoltan Kiska, Tomas Zvoncak, Vojtech Mucha, Jan Smekal, Zdenek Eliasova, Ilona Kostalova, Milena Mrackova, Martina Fiedorova, Dagmar Faundez-Zanuy, Marcos Solé-Casals, Jordi Gomez-Vilda, Pedro Rektorova, Irena Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title | Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title_full | Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title_fullStr | Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title_full_unstemmed | Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title_short | Quantitative Analysis of Relationship Between Hypokinetic Dysarthria and the Freezing of Gait in Parkinson’s Disease |
title_sort | quantitative analysis of relationship between hypokinetic dysarthria and the freezing of gait in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294819/ https://www.ncbi.nlm.nih.gov/pubmed/30595758 http://dx.doi.org/10.1007/s12559-018-9575-8 |
work_keys_str_mv | AT mekyskajiri quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT galazzoltan quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT kiskatomas quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT zvoncakvojtech quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT muchajan quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT smekalzdenek quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT eliasovailona quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT kostalovamilena quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT mrackovamartina quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT fiedorovadagmar quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT faundezzanuymarcos quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT solecasalsjordi quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT gomezvildapedro quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease AT rektorovairena quantitativeanalysisofrelationshipbetweenhypokineticdysarthriaandthefreezingofgaitinparkinsonsdisease |