DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death

The poor prognosis of ovarian cancer (it is the leading cause of death from gynecological cancers) is mainly due to the acquisition of resistance to carboplatin. Among the possible resistance pathways, resistance to apoptosis and especially the overexpression of inhibitor of apoptosis proteins (IAP)...

Descripción completa

Detalles Bibliográficos
Autores principales: Thibault, Benoît, Genre, Ludivine, Le Naour, Augustin, Broca, Clothilde, Mery, Eliane, Vuagniaux, Grégoire, Delord, Jean Pierre, Wiedemann, Norbert, Couderc, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294826/
https://www.ncbi.nlm.nih.gov/pubmed/30552344
http://dx.doi.org/10.1038/s41598-018-35860-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294826/
https://www.ncbi.nlm.nih.gov/pubmed/30552344
http://dx.doi.org/10.1038/s41598-018-35860-z

Ejemplares similares