Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening

Familial amyloid polyneuropathy is a hereditary systemic amyloidosis caused by a mutation in the transthyretin (TTR) gene. Amyloid deposits in tissues of patients contain not only full-length TTR but also C-terminal TTR fragments. However, in vivo models to evaluate the pathogenicity of TTR fragment...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsuda, Yukimoto, Yamanaka, Kunitoshi, Toyoshima, Risa, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ogura, Teru, Ando, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294829/
https://www.ncbi.nlm.nih.gov/pubmed/30552363
http://dx.doi.org/10.1038/s41598-018-36357-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294829/
https://www.ncbi.nlm.nih.gov/pubmed/30552363
http://dx.doi.org/10.1038/s41598-018-36357-5

Ejemplares similares