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Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening
Familial amyloid polyneuropathy is a hereditary systemic amyloidosis caused by a mutation in the transthyretin (TTR) gene. Amyloid deposits in tissues of patients contain not only full-length TTR but also C-terminal TTR fragments. However, in vivo models to evaluate the pathogenicity of TTR fragment...
Autores principales: | Tsuda, Yukimoto, Yamanaka, Kunitoshi, Toyoshima, Risa, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ogura, Teru, Ando, Yukio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294829/ https://www.ncbi.nlm.nih.gov/pubmed/30552363 http://dx.doi.org/10.1038/s41598-018-36357-5 |
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