CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1

Natural killer (NK) cell recognition of tumor cells is mediated through activating receptors such as CD226, with suppression of effector functions often controlled by negative regulatory transcription factors such as FOXO1. Here we show that CD226 regulation of NK cell cytotoxicity is facilitated th...

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Detalles Bibliográficos
Autores principales: Du, Xiangnan, de Almeida, Patricia, Manieri, Nick, de Almeida Nagata, Denise, Wu, Thomas D., Harden Bowles, Kristin, Arumugam, Vidhyalakshmi, Schartner, Jill, Cubas, Rafael, Mittman, Stephanie, Javinal, Vincent, Anderson, Keith R., Warming, Søren, Grogan, Jane L., Chiang, Eugene Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294892/
https://www.ncbi.nlm.nih.gov/pubmed/30504141
http://dx.doi.org/10.1073/pnas.1814052115

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