Cargando…
DksA–DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase
RNA polymerase is the only known protein partner of the transcriptional regulator DksA. Herein, we demonstrate that the chaperone DnaJ establishes direct, redox-based interactions with oxidized DksA. Cysteine residues in the zinc finger of DksA become oxidized in Salmonella exposed to low concentrat...
Autores principales: | Kim, Ju-Sim, Liu, Lin, Fitzsimmons, Liam F., Wang, Yang, Crawford, Matthew A., Mastrogiovanni, Mauricio, Trujillo, Madia, Till, James Karl A., Radi, Rafael, Dai, Shaodong, Vázquez-Torres, Andrés |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294903/ https://www.ncbi.nlm.nih.gov/pubmed/30429329 http://dx.doi.org/10.1073/pnas.1813572115 |
Ejemplares similares
-
Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content
por: Crawford, Matthew A., et al.
Publicado: (2016) -
The DnaK/DnaJ Chaperone System Enables RNA Polymerase-DksA Complex Formation in Salmonella Experiencing Oxidative Stress
por: Kim, Ju-Sim, et al.
Publicado: (2021) -
pH Dependence of the Stress Regulator DksA
por: Furman, Ran, et al.
Publicado: (2015) -
DksA Modulates Antimicrobial Susceptibility of Acinetobacter baumannii
por: Kim, Nayeong, et al.
Publicado: (2021) -
Expression and structure of the Chlamydia trachomatis DksA ortholog
por: Mandel, Cameron, et al.
Publicado: (2022)