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Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture
Tumorigenesis depends on intricate interactions between genetically altered tumor cells and their surrounding microenvironment. While oncogenic drivers in lung squamous carcinoma (LUSC) have been described, the role of stroma in modulating tissue architecture, particularly cell polarity, remains unc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294935/ https://www.ncbi.nlm.nih.gov/pubmed/30487219 http://dx.doi.org/10.1073/pnas.1803718115 |