Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins

T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from lo...

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Detalles Bibliográficos
Autores principales: Pogorelyy, Mikhail V., Minervina, Anastasia A., Touzel, Maximilian Puelma, Sycheva, Anastasiia L., Komech, Ekaterina A., Kovalenko, Elena I., Karganova, Galina G., Egorov, Evgeniy S., Komkov, Alexander Yu., Chudakov, Dmitriy M., Mamedov, Ilgar Z., Mora, Thierry, Walczak, Aleksandra M., Lebedev, Yuri B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294963/
https://www.ncbi.nlm.nih.gov/pubmed/30459272
http://dx.doi.org/10.1073/pnas.1809642115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294963/
https://www.ncbi.nlm.nih.gov/pubmed/30459272
http://dx.doi.org/10.1073/pnas.1809642115

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