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Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar

OBJECTIVES: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can sur...

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Autores principales: Andrianaivoarimanana, Voahangy, Rajerison, Minoarisoa, Jambou, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295079/
https://www.ncbi.nlm.nih.gov/pubmed/30551741
http://dx.doi.org/10.1186/s13104-018-3984-3
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author Andrianaivoarimanana, Voahangy
Rajerison, Minoarisoa
Jambou, Ronan
author_facet Andrianaivoarimanana, Voahangy
Rajerison, Minoarisoa
Jambou, Ronan
author_sort Andrianaivoarimanana, Voahangy
collection PubMed
description OBJECTIVES: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. RESULTS: Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3984-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-62950792018-12-18 Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar Andrianaivoarimanana, Voahangy Rajerison, Minoarisoa Jambou, Ronan BMC Res Notes Research Note OBJECTIVES: In Madagascar, plague (Yersinia pestis infection) is endemic in the central highlands, maintained by the couple Rattus rattus/flea. The rat is assumed to die shortly after infection inducing migration of the fleas. However we previously reported that black rats from endemic areas can survive the infection whereas those from non-endemic areas remained susceptible. We investigate the hypothesis that lineages of rats can acquire resistance to plague and that previous contacts with the bacteria will affect their survival, allowing maintenance of infected fleas. For this purpose, laboratory-born rats were obtained from wild black rats originating either from plague-endemic or plague-free zones, and were challenged with Y. pestis. Survival rate and antibody immune responses were analyzed. RESULTS: Inoculation of low doses of Y. pestis greatly increase survival of rats to subsequent challenge with a lethal dose. During challenge, cytokine profiles support activation of specific immune response associated with the bacteria control. In addition, F1 rats from endemic areas exhibited higher survival rates than those from non-endemic ones, suggesting a selection of a resistant lineage. In Madagascar, these results support the role of black rat as long term reservoir of infected fleas supporting maintenance of plague transmission. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13104-018-3984-3) contains supplementary material, which is available to authorized users. BioMed Central 2018-12-14 /pmc/articles/PMC6295079/ /pubmed/30551741 http://dx.doi.org/10.1186/s13104-018-3984-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Andrianaivoarimanana, Voahangy
Rajerison, Minoarisoa
Jambou, Ronan
Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title_full Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title_fullStr Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title_full_unstemmed Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title_short Exposure to Yersinia pestis increases resistance to plague in black rats and modulates transmission in Madagascar
title_sort exposure to yersinia pestis increases resistance to plague in black rats and modulates transmission in madagascar
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295079/
https://www.ncbi.nlm.nih.gov/pubmed/30551741
http://dx.doi.org/10.1186/s13104-018-3984-3
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