A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

We combine single-cell RNA-seq and in vivo lineage tracing to study the cellular composition and hierarchy of the murine tracheal epithelium. We identify a new rare cell type, the FoxI1-positive pulmonary ionocyte; functional variations in club cells based on their proximodistal location; a distinct...

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Detalles Bibliográficos
Autores principales: Montoro, Daniel T., Haber, Adam L., Biton, Moshe, Vinarsky, Vladimir, Lin, Brian, Birket, Susan, Yuan, Feng, Chen, Sijia, Leung, Hui Min, Villoria, Jorge, Rogel, Noga, Burgin, Grace, Tsankov, Alexander, Waghray, Avinash, Slyper, Michal, Waldmann, Julia, Nguyen, Lan, Dionne, Danielle, Rozenblatt-Rosen, Orit, Tata, Purushothama Rao, Mou, Hongmei, Shivaraju, Manjunatha, Bihler, Hermann, Mense, Martin, Tearney, Guillermo J., Rowe, Steven M., Engelhardt, John F., Regev, Aviv, Rajagopal, Jayaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295155/
https://www.ncbi.nlm.nih.gov/pubmed/30069044
http://dx.doi.org/10.1038/s41586-018-0393-7

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