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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295163/ https://www.ncbi.nlm.nih.gov/pubmed/30478249 http://dx.doi.org/10.1101/gad.317362.118 |
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author | Son, Heehwa G. Seo, Keunhee Seo, Mihwa Park, Sangsoon Ham, Seokjin An, Seon Woo A. Choi, Eun-Seok Lee, Yujin Baek, Haeshim Kim, Eunju Ryu, Youngjae Ha, Chang Man Hsu, Ao-Lin Roh, Tae-Young Jang, Sung Key Lee, Seung-Jae V. |
author_facet | Son, Heehwa G. Seo, Keunhee Seo, Mihwa Park, Sangsoon Ham, Seokjin An, Seon Woo A. Choi, Eun-Seok Lee, Yujin Baek, Haeshim Kim, Eunju Ryu, Youngjae Ha, Chang Man Hsu, Ao-Lin Roh, Tae-Young Jang, Sung Key Lee, Seung-Jae V. |
author_sort | Son, Heehwa G. |
collection | PubMed |
description | Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS. |
format | Online Article Text |
id | pubmed-6295163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62951632019-06-01 Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans Son, Heehwa G. Seo, Keunhee Seo, Mihwa Park, Sangsoon Ham, Seokjin An, Seon Woo A. Choi, Eun-Seok Lee, Yujin Baek, Haeshim Kim, Eunju Ryu, Youngjae Ha, Chang Man Hsu, Ao-Lin Roh, Tae-Young Jang, Sung Key Lee, Seung-Jae V. Genes Dev Research Paper Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS. Cold Spring Harbor Laboratory Press 2018-12-01 /pmc/articles/PMC6295163/ /pubmed/30478249 http://dx.doi.org/10.1101/gad.317362.118 Text en © 2018 Son et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Paper Son, Heehwa G. Seo, Keunhee Seo, Mihwa Park, Sangsoon Ham, Seokjin An, Seon Woo A. Choi, Eun-Seok Lee, Yujin Baek, Haeshim Kim, Eunju Ryu, Youngjae Ha, Chang Man Hsu, Ao-Lin Roh, Tae-Young Jang, Sung Key Lee, Seung-Jae V. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title_full | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title_fullStr | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title_full_unstemmed | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title_short | Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans |
title_sort | prefoldin 6 mediates longevity response from heat shock factor 1 to foxo in c. elegans |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295163/ https://www.ncbi.nlm.nih.gov/pubmed/30478249 http://dx.doi.org/10.1101/gad.317362.118 |
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