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Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder

Emerging evidence has documented the abnormalities of primary brain functions in major depressive disorder (MDD). The brainstem has shown to play an important role in regulating basic functions of the human brain, but little is known about its role in MDD, especially the roles of its subregions. To...

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Autores principales: Luo, Lizhu, Wu, Kunhua, Lu, Yi, Gao, Shan, Kong, Xiangchao, Lu, Fengmei, Wu, Fengchun, Wu, Huawang, Wang, Jiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295569/
https://www.ncbi.nlm.nih.gov/pubmed/30618555
http://dx.doi.org/10.3389/fnins.2018.00926
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author Luo, Lizhu
Wu, Kunhua
Lu, Yi
Gao, Shan
Kong, Xiangchao
Lu, Fengmei
Wu, Fengchun
Wu, Huawang
Wang, Jiaojian
author_facet Luo, Lizhu
Wu, Kunhua
Lu, Yi
Gao, Shan
Kong, Xiangchao
Lu, Fengmei
Wu, Fengchun
Wu, Huawang
Wang, Jiaojian
author_sort Luo, Lizhu
collection PubMed
description Emerging evidence has documented the abnormalities of primary brain functions in major depressive disorder (MDD). The brainstem has shown to play an important role in regulating basic functions of the human brain, but little is known about its role in MDD, especially the roles of its subregions. To uncover this, the present study adopted resting-state functional magnetic resonance imaging with fine-grained brainstem atlas in 23 medication-free MDD patients and 34 matched healthy controls (HC). The analysis revealed significantly increased functional connectivity of the medulla, one of the brainstem subregions, with the inferior parietal cortex (IPC) in MDD patients. A positive correlation was further identified between the increased medulla-IPC functional connectivity and Hamilton anxiety scores. Functional characterization of the medulla and IPC using a meta-analysis revealed that both regions primarily participated in action execution and inhibition. Our findings suggest that increased medulla-IPC functional connectivity may be related to over-activity or abnormal control of negative emotions in MDD, which provides a new insight for the neurobiology of MDD.
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spelling pubmed-62955692019-01-07 Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder Luo, Lizhu Wu, Kunhua Lu, Yi Gao, Shan Kong, Xiangchao Lu, Fengmei Wu, Fengchun Wu, Huawang Wang, Jiaojian Front Neurosci Neuroscience Emerging evidence has documented the abnormalities of primary brain functions in major depressive disorder (MDD). The brainstem has shown to play an important role in regulating basic functions of the human brain, but little is known about its role in MDD, especially the roles of its subregions. To uncover this, the present study adopted resting-state functional magnetic resonance imaging with fine-grained brainstem atlas in 23 medication-free MDD patients and 34 matched healthy controls (HC). The analysis revealed significantly increased functional connectivity of the medulla, one of the brainstem subregions, with the inferior parietal cortex (IPC) in MDD patients. A positive correlation was further identified between the increased medulla-IPC functional connectivity and Hamilton anxiety scores. Functional characterization of the medulla and IPC using a meta-analysis revealed that both regions primarily participated in action execution and inhibition. Our findings suggest that increased medulla-IPC functional connectivity may be related to over-activity or abnormal control of negative emotions in MDD, which provides a new insight for the neurobiology of MDD. Frontiers Media S.A. 2018-12-10 /pmc/articles/PMC6295569/ /pubmed/30618555 http://dx.doi.org/10.3389/fnins.2018.00926 Text en Copyright © 2018 Luo, Wu, Lu, Gao, Kong, Lu, Wu, Wu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Luo, Lizhu
Wu, Kunhua
Lu, Yi
Gao, Shan
Kong, Xiangchao
Lu, Fengmei
Wu, Fengchun
Wu, Huawang
Wang, Jiaojian
Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title_full Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title_fullStr Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title_full_unstemmed Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title_short Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
title_sort increased functional connectivity between medulla and inferior parietal cortex in medication-free major depressive disorder
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295569/
https://www.ncbi.nlm.nih.gov/pubmed/30618555
http://dx.doi.org/10.3389/fnins.2018.00926
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