Cargando…

Δ(9)-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure

PURPOSE: It has been known for nearly 50 years that cannabis and the psychoactive constituent Δ(9)-tetrahydrocannabinol (THC) reduce intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a major cause of blindness. THC likely acts via one of the kno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Sally, Daily, Laura, Leishman, Emma, Bradshaw, Heather, Straiker, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2018
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295937/ https://www.ncbi.nlm.nih.gov/pubmed/30550613 http://dx.doi.org/10.1167/iovs.18-24838

Ejemplares similares

Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure
por: Miller, Sally, et al.
Publicado: (2016)

Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model
por: Miller, Sally, et al.
Publicado: (2016)

A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner
por: Miller, Sally, et al.
Publicado: (2017)

Development of a Δ(9)-Tetrahydrocannabinol Amino Acid-Dicarboxylate Prodrug With Improved Ocular Bioavailability
por: Adelli, Goutham R., et al.
Publicado: (2017)

Chronic Adolescent Δ(9)-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment
por: Murphy, Michelle, et al.
Publicado: (2017)

Toxicological Properties of Δ(9)-tetrahydrocannabinol and Cannabidiol
por: Černe, Katarina
Publicado: (2020)

Continuous-Flow Synthesis of Δ(9)-Tetrahydrocannabinol and Δ(8)-Tetrahydrocannabinol from Cannabidiol
por: Bassetti, Benedetta, et al.
Publicado: (2023)

Intraocular pressure fluctuation during resistance exercise
por: Vaghefi, Ehsan, et al.
Publicado: (2021)

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study
por: Plotnikov, Denis, et al.
Publicado: (2022)

Cannabidiol Does Not Convert to Δ(9)-Tetrahydrocannabinol in an In Vivo Animal Model
por: Wray, Louise, et al.
Publicado: (2017)

Comparative Metabolomic Profiling of the Metabolic Differences of Δ9-Tetrahydrocannabinol and Cannabidiol
por: Rao, Qianru, et al.
Publicado: (2022)

Transient Intraocular Pressure Fluctuations: Source, Magnitude, Frequency, and Associated Mechanical Energy
por: Turner, Daniel C., et al.
Publicado: (2019)

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases
por: Brazile, Bryn L., et al.
Publicado: (2020)

Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients
por: Pillunat, Karin R., et al.
Publicado: (2022)

The Effect of Change in Intraocular Pressure on Choroidal Structure in Glaucomatous Eyes
por: Zhang, Xuemin, et al.
Publicado: (2017)

Adrenal and Glucocorticoid Effects on the Circadian Rhythm of Murine Intraocular Pressure
por: Tsuchiya, Shunsuke, et al.
Publicado: (2018)

Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract
por: Wakshlag, Joseph J., et al.
Publicado: (2020)

Δ(9)-Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits
por: Taskar, Pranjal S., et al.
Publicado: (2019)

The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase
por: Muenster, Stefan, et al.
Publicado: (2017)

Intraocular Pressure Elevation Compromises Retinal Ganglion Cell Light Adaptation
por: Tao, Xiaofeng, et al.
Publicado: (2020)

Proposed Mechanism of Long-Term Intraocular Pressure Lowering With the Bimatoprost Implant
por: Stamer, W. Daniel, et al.
Publicado: (2023)

Paraventricular Hypothalamic Nucleus Upregulates Intraocular Pressure Via Glutamatergic Neurons
por: Ma, Lin, et al.
Publicado: (2023)

Combinations of Cannabidiol and Δ(9)-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain
por: Sepulveda, Diana E., et al.
Publicado: (2022)

The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model
por: Fazio, Massimo A., et al.
Publicado: (2019)

The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure
por: Webber, Hannah C., et al.
Publicado: (2018)

Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure
por: Faralli, Jennifer A., et al.
Publicado: (2019)

Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes
por: Zhao, Da, et al.
Publicado: (2020)

Immediate Impact of Acute Elevation of Intraocular Pressure on Cortical Visual Motion Processing
por: Yuan, Nini, et al.
Publicado: (2020)

Posture-Related Changes of Intraocular Pressure in Patients With Acute Primary Angle Closure
por: Hsia, Yun, et al.
Publicado: (2021)

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes
por: Nemoto, Hotaka, et al.
Publicado: (2022)

Role of excessive weight in intraocular pressure: a systematic review and meta-analysis
por: Waspodo, Noro, et al.
Publicado: (2023)

Risk Factors Associated with Structural Progression in Normal-Tension Glaucoma: Intraocular Pressure, Systemic Blood Pressure, and Myopia
por: Lee, Kwanghyun, et al.
Publicado: (2020)

Long-term follow-up of intraocular pressure and pressure-lowering medication in patients following Excimer laser trabeculotomy
por: Deubel, C., et al.
Publicado: (2020)

Beyond Δ9-tetrahydrocannabinol and cannabidiol: chemical differentiation of cannabis varieties applying targeted and untargeted analysis
por: Monti, Manuela Carla, et al.
Publicado: (2022)

Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram Responses
por: Choh, Vivian, et al.
Publicado: (2016)

Effects of Lentivirus-Mediated C3 Expression on Trabecular Meshwork Cells and Intraocular Pressure
por: Tan, Junka, et al.
Publicado: (2018)

Effects of Chronic and Acute Intraocular Pressure Elevation on Scotopic and Photopic Contrast Sensitivity in Mice
por: van der Heijden, Meike E., et al.
Publicado: (2016)

Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma
por: Tang, Jessica, et al.
Publicado: (2020)

Neuroretinal Rim Response to Transient Intraocular Pressure Challenge Predicts the Extent of Retinal Ganglion Cell Loss in Experimental Glaucoma
por: Patel, Nimesh B., et al.
Publicado: (2023)

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial
por: Zamarripa, C. Austin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lmbgh71lrgjokgvqsbpfvv092t