Cargando…

Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy

PURPOSE: The purpose of this study was to investigate the effect of reducing diabetes-induced lysyl oxidase (LOX) overexpression on vascular cell apoptosis and blood–retinal barrier (BRB) characteristics in diabetic rats. METHODS: Nondiabetic rats, diabetic rats, and diabetic rats intravitreally (IV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Brian, Kim, Dongjoon, Nguyen, Ngan-Ha, Roy, Sayon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2018
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295938/ https://www.ncbi.nlm.nih.gov/pubmed/30550614 http://dx.doi.org/10.1167/iovs.18-25543

Ejemplares similares

High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy
por: Nguyen, Ngan-Ha, et al.
Publicado: (2020)

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis
por: Kim, Dongjoon, et al.
Publicado: (2017)

Effects of Diabetes on Mitochondrial Morphology and Its Implications in Diabetic Retinopathy
por: Kim, Dongjoon, et al.
Publicado: (2020)

High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy
por: Tien, Thomas, et al.
Publicado: (2017)

Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy
por: Subramanian, Manju L., et al.
Publicado: (2019)

Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy
por: Kim, Dongjoon, et al.
Publicado: (2021)

Reduced Levels of Drp1 Protect against Development of Retinal Vascular Lesions in Diabetic Retinopathy
por: Kim, Dongjoon, et al.
Publicado: (2021)

Photoreceptor Degeneration Accompanies Vascular Changes in a Zebrafish Model of Diabetic Retinopathy
por: Ali, Zaheer, et al.
Publicado: (2020)

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2(Akita/+) Murine Model of Diabetic Retinopathy
por: Wang, Jing, et al.
Publicado: (2016)

Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity
por: Han, Xiaokun, et al.
Publicado: (2019)

Hydrogen Sulfide Contributes to Retinal Neovascularization in Ischemia-Induced Retinopathy
por: Gersztenkorn, David, et al.
Publicado: (2016)

Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy
por: Duraisamy, Arul J., et al.
Publicado: (2018)

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
por: Lessieur, Emma M., et al.
Publicado: (2021)

Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy
por: Mohammad, Ghulam, et al.
Publicado: (2020)

The relationship of diabetic retinopathy severity scales with frequency and surface area of diabetic retinopathy lesions
por: Esmaeilkhanian, Houri, et al.
Publicado: (2023)

Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy
por: Trackman, Philip C., et al.
Publicado: (2022)

Diabetes Modulates Iodothyronine Deiodinase 2 Expression in the Mouse Retina: A Role for Thyroid Hormone in the Pathogenesis of Diabetic Retinopathy
por: Bapputty, Reena, et al.
Publicado: (2023)

Epigenetic Modifications Compromise Mitochondrial DNA Quality Control in the Development of Diabetic Retinopathy
por: Mohammad, Ghulam, et al.
Publicado: (2019)

MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy
por: Wang, Eric, et al.
Publicado: (2023)

Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy
por: Mishra, Manish, et al.
Publicado: (2016)

The Role of DNA Methylation in the Metabolic Memory Phenomenon Associated With the Continued Progression of Diabetic Retinopathy
por: Mishra, Manish, et al.
Publicado: (2016)

Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy
por: McLaughlin, Todd, et al.
Publicado: (2023)

The Nicotinic Cholinergic Pathway Contributes to Retinal Neovascularization in a Mouse Model of Retinopathy of Prematurity
por: Hackett, Sean F., et al.
Publicado: (2017)

Young Ossabaw Pigs Fed a Western Diet Exhibit Early Signs of Diabetic Retinopathy
por: Lim, Rayne R., et al.
Publicado: (2018)

The Long Non-Coding RNA HOTAIR Is a Critical Epigenetic Mediator of Angiogenesis in Diabetic Retinopathy
por: Biswas, Saumik, et al.
Publicado: (2021)

Regulation of Spermine Oxidase through Hypoxia-Inducible Factor-1α Signaling in Retinal Glial Cells under Hypoxic Conditions
por: Wu, Di, et al.
Publicado: (2020)

Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes
por: Duraisamy, Arul J., et al.
Publicado: (2017)

Effect of sulodexide in patients with non-proliferative diabetic retinopathy: diabetic retinopathy sulodexide study (DRESS)
por: Song, Ji Hun, et al.
Publicado: (2014)

Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice
por: Shu, Wanting, et al.
Publicado: (2019)

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease
por: Edwards, Malia M., et al.
Publicado: (2020)

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity
por: Shaw, Lynn Calvin, et al.
Publicado: (2018)

Key considerations when choosing a retinal camera for diabetic retinopathy screening
por: Bascaran, Covadonga
Publicado: (2023)

Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy
por: Roy, Sayon, et al.
Publicado: (2019)

Viral Retinopathy in Experimental Models of Zika Infection
por: Zhao, Zhenyang, et al.
Publicado: (2017)

Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer
por: Glass, Joshua, et al.
Publicado: (2023)

Adenosine Deaminase-2–Induced Hyperpermeability in Human Retinal Vascular Endothelial Cells Is Suppressed by MicroRNA-146b-3p
por: Samra, Yara A., et al.
Publicado: (2017)

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis
por: Wakabayashi, Taku, et al.
Publicado: (2022)

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
por: Song, Hongman, et al.
Publicado: (2016)

Neuroprotective Effects of HSF1 in Retinal Ischemia-Reperfusion Injury
por: Liu, Wei, et al.
Publicado: (2019)

PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy
por: Shi, Shuizhen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_61o3b2lvdas6kcfklpkkqeng5u