Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

BACKGROUND: Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer’s disease (AD). However, the gene expression changes underlying microglia activation in response to tau pathology remain elusive. Furthermore, it is not cle...

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Detalles Bibliográficos
Autores principales: Wang, Hong, Li, Yupeng, Ryder, John W., Hole, Justin T., Ebert, Philip J., Airey, David C., Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K., Cavallini, Annalisa, Bose, Suchira, Eastwood, Brian J., Collier, David A., Dage, Jeffrey L., Miller, Bradley B., Merchant, Kalpana M., O’Neill, Michael J., Demattos, Ronald B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296031/
https://www.ncbi.nlm.nih.gov/pubmed/30558641
http://dx.doi.org/10.1186/s13024-018-0296-y

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