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Transient receptor potential ankyrin 1 (trpa1) mediates il-1β-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction

BACKGROUND: Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca(2+)), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated ca...

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Detalles Bibliográficos
Autores principales:	Yin, Songjiang, Zhang, Li, Ding, Liang, Huang, Zhengquan, Xu, Bo, Li, XiaoChen, Wang, Peimin, Mao, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296079/ https://www.ncbi.nlm.nih.gov/pubmed/30564065 http://dx.doi.org/10.1186/s12950-018-0204-9

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