Pulmonary aspiration in preschool children with cystic fibrosis

Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) flu...

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Autores principales: Clarke, D., Gorman, I., Ringholz, F., McDermott, M., Cox, DW., Greally, P., Linnane, B., Mc Nally, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296125/
https://www.ncbi.nlm.nih.gov/pubmed/30558606
http://dx.doi.org/10.1186/s12931-018-0954-1
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author Clarke, D.
Gorman, I.
Ringholz, F.
McDermott, M.
Cox, DW.
Greally, P.
Linnane, B.
Mc Nally, P.
author_facet Clarke, D.
Gorman, I.
Ringholz, F.
McDermott, M.
Cox, DW.
Greally, P.
Linnane, B.
Mc Nally, P.
author_sort Clarke, D.
collection PubMed
description Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.
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spelling pubmed-62961252018-12-18 Pulmonary aspiration in preschool children with cystic fibrosis Clarke, D. Gorman, I. Ringholz, F. McDermott, M. Cox, DW. Greally, P. Linnane, B. Mc Nally, P. Respir Res Letter to the Editor Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms. BioMed Central 2018-12-17 2018 /pmc/articles/PMC6296125/ /pubmed/30558606 http://dx.doi.org/10.1186/s12931-018-0954-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Clarke, D.
Gorman, I.
Ringholz, F.
McDermott, M.
Cox, DW.
Greally, P.
Linnane, B.
Mc Nally, P.
Pulmonary aspiration in preschool children with cystic fibrosis
title Pulmonary aspiration in preschool children with cystic fibrosis
title_full Pulmonary aspiration in preschool children with cystic fibrosis
title_fullStr Pulmonary aspiration in preschool children with cystic fibrosis
title_full_unstemmed Pulmonary aspiration in preschool children with cystic fibrosis
title_short Pulmonary aspiration in preschool children with cystic fibrosis
title_sort pulmonary aspiration in preschool children with cystic fibrosis
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296125/
https://www.ncbi.nlm.nih.gov/pubmed/30558606
http://dx.doi.org/10.1186/s12931-018-0954-1
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