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Abdominal Sepsis: An Update
Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296273/ https://www.ncbi.nlm.nih.gov/pubmed/30574564 http://dx.doi.org/10.2478/jccm-2018-0023 |
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author | Mureșan, Mircea Gabriel Balmoș, Ioan Alexandru Badea, Iudita Santini, Ario |
author_facet | Mureșan, Mircea Gabriel Balmoș, Ioan Alexandru Badea, Iudita Santini, Ario |
author_sort | Mureșan, Mircea Gabriel |
collection | PubMed |
description | Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelines as recommended by the Intra-abdominal Infection (IAI) Consensus (2017). Prognostic scores are currently used to assess the course of peritonitis. Irrespective of the initial cause, there are several measures universally accepted as contributing to an improved survival rate, with the early recognition of IAI being the critical matter in this respect. Immediate correction of fluid balance should be undertaken with the use of vasoactive agents being prescribed, if necessary, to augment and assist fluid resuscitation. The WISS study showed that mortality was significantly affected by sepsis irrespective of any medical and surgical measures. A significant issue is the prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in the clinical setting, and the reported prevalence of ESBLs intra-abdominal infections has steadily increased in Asia. Europe, Latin America, Middle East, North America, and South Pacific. Abdominal cavity pathology is second only to sepsis occurring in a pulmonary site. Following IAI (2017) guidelines, antibiotic therapy should be initiated as soon as possible after a diagnosis has been verified. |
format | Online Article Text |
id | pubmed-6296273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-62962732018-12-20 Abdominal Sepsis: An Update Mureșan, Mircea Gabriel Balmoș, Ioan Alexandru Badea, Iudita Santini, Ario J Crit Care Med (Targu Mures) Review Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelines as recommended by the Intra-abdominal Infection (IAI) Consensus (2017). Prognostic scores are currently used to assess the course of peritonitis. Irrespective of the initial cause, there are several measures universally accepted as contributing to an improved survival rate, with the early recognition of IAI being the critical matter in this respect. Immediate correction of fluid balance should be undertaken with the use of vasoactive agents being prescribed, if necessary, to augment and assist fluid resuscitation. The WISS study showed that mortality was significantly affected by sepsis irrespective of any medical and surgical measures. A significant issue is the prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in the clinical setting, and the reported prevalence of ESBLs intra-abdominal infections has steadily increased in Asia. Europe, Latin America, Middle East, North America, and South Pacific. Abdominal cavity pathology is second only to sepsis occurring in a pulmonary site. Following IAI (2017) guidelines, antibiotic therapy should be initiated as soon as possible after a diagnosis has been verified. Sciendo 2018-10-01 /pmc/articles/PMC6296273/ /pubmed/30574564 http://dx.doi.org/10.2478/jccm-2018-0023 Text en © 2018 Mircea Gabriel Mureșan, Ioan Alexandru Balmoș, Iudita Badea, Ario Santini published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Review Mureșan, Mircea Gabriel Balmoș, Ioan Alexandru Badea, Iudita Santini, Ario Abdominal Sepsis: An Update |
title | Abdominal Sepsis: An Update |
title_full | Abdominal Sepsis: An Update |
title_fullStr | Abdominal Sepsis: An Update |
title_full_unstemmed | Abdominal Sepsis: An Update |
title_short | Abdominal Sepsis: An Update |
title_sort | abdominal sepsis: an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296273/ https://www.ncbi.nlm.nih.gov/pubmed/30574564 http://dx.doi.org/10.2478/jccm-2018-0023 |
work_keys_str_mv | AT muresanmirceagabriel abdominalsepsisanupdate AT balmosioanalexandru abdominalsepsisanupdate AT badeaiudita abdominalsepsisanupdate AT santiniario abdominalsepsisanupdate |