Silver-mediated oxidative functionalization of alkylsilanes

A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported. This strategy encompasses a range of valuable C–Si transformations, including the direct conversions of a C–Si bond to C–OCF(3), C–OBz, C–OCOCF(3), C–SCF(3), C–SCN, and...

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Detalles Bibliográficos
Autores principales: Wang, Feng, Xu, Peng, Cong, Fei, Tang, Pingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296296/
https://www.ncbi.nlm.nih.gov/pubmed/30627401
http://dx.doi.org/10.1039/c8sc03730b
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author Wang, Feng
Xu, Peng
Cong, Fei
Tang, Pingping
author_facet Wang, Feng
Xu, Peng
Cong, Fei
Tang, Pingping
author_sort Wang, Feng
collection PubMed
description A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported. This strategy encompasses a range of valuable C–Si transformations, including the direct conversions of a C–Si bond to C–OCF(3), C–OBz, C–OCOCF(3), C–SCF(3), C–SCN, and C–N(3) bonds. Among them, trifluoromethoxylation of alkylsilanes is reported for the first time. In addition, mechanistic studies indicate that this reaction may proceed through a radical mechanism.
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spelling pubmed-62962962019-01-09 Silver-mediated oxidative functionalization of alkylsilanes Wang, Feng Xu, Peng Cong, Fei Tang, Pingping Chem Sci Chemistry A general approach to the functionalization of aliphatic C–Si bonds in the presence of silver salts and oxidants has been reported. This strategy encompasses a range of valuable C–Si transformations, including the direct conversions of a C–Si bond to C–OCF(3), C–OBz, C–OCOCF(3), C–SCF(3), C–SCN, and C–N(3) bonds. Among them, trifluoromethoxylation of alkylsilanes is reported for the first time. In addition, mechanistic studies indicate that this reaction may proceed through a radical mechanism. Royal Society of Chemistry 2018-09-24 /pmc/articles/PMC6296296/ /pubmed/30627401 http://dx.doi.org/10.1039/c8sc03730b Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Wang, Feng
Xu, Peng
Cong, Fei
Tang, Pingping
Silver-mediated oxidative functionalization of alkylsilanes
title Silver-mediated oxidative functionalization of alkylsilanes
title_full Silver-mediated oxidative functionalization of alkylsilanes
title_fullStr Silver-mediated oxidative functionalization of alkylsilanes
title_full_unstemmed Silver-mediated oxidative functionalization of alkylsilanes
title_short Silver-mediated oxidative functionalization of alkylsilanes
title_sort silver-mediated oxidative functionalization of alkylsilanes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296296/
https://www.ncbi.nlm.nih.gov/pubmed/30627401
http://dx.doi.org/10.1039/c8sc03730b
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AT xupeng silvermediatedoxidativefunctionalizationofalkylsilanes
AT congfei silvermediatedoxidativefunctionalizationofalkylsilanes
AT tangpingping silvermediatedoxidativefunctionalizationofalkylsilanes

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