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Dose-finding designs for cumulative toxicities using multiple constraints

This article addresses the concern regarding late-onset dose-limiting toxicities (DLT), moderate toxicities below the threshold of a DLT and cumulative toxicities that may lead to a DLT, which are mostly disregarded or handled in an ad hoc manner when determining the maximum tolerated dose (MTD) in...

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Detalles Bibliográficos
Autores principales:	Lee, Shing M, Ursino, Moreno, Cheung, Ying Kuen, Zohar, Sarah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296314/ https://www.ncbi.nlm.nih.gov/pubmed/29140414 http://dx.doi.org/10.1093/biostatistics/kxx059

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