CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis

Metabolic dysfunction is a hallmark of gastric cancer (GC). In this study, we reported the identification of Calcium Binding Protein 39-Like (CAB39L) as a novel regulator of tumor metabolism in GC. CAB39L mRNA was frequently silenced by promoter methylation in GC cell lines and tissues. Functional s...

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Detalles Bibliográficos
Autores principales: Li, Weilin, Wong, Chi Chun, Zhang, Xiaoming, Kang, Wei, Nakatsu, Geicho, Zhao, Qinfu, Chen, Huarong, Go, Minnie Yin Yin, Chiu, Philip Wai Yan, Wang, Xiaohong, Ji, Jiafu, Li, Xiaona, Cai, Zongwei, Ng, Enders Kwok Wai, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296350/
https://www.ncbi.nlm.nih.gov/pubmed/30054562
http://dx.doi.org/10.1038/s41388-018-0402-1

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