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Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats

The Insulin-like Growth Factor 1 (IGF1) gene is a member of somatotropic axis and plays a key role in proliferation of cells, mitosis, myogenesis, meiosis, differentiation in foetal development and post natal growth. The objectives of this study were to verify the single nucleotide polymorphisms (SN...

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Autores principales: Naicy, Thomas, Venkatachalapathy, R.T., Aravindakshan, T.V., Kurian, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Scientific Research and Technology, Egypt 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296596/
https://www.ncbi.nlm.nih.gov/pubmed/30647636
http://dx.doi.org/10.1016/j.jgeb.2017.04.002
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author Naicy, Thomas
Venkatachalapathy, R.T.
Aravindakshan, T.V.
Kurian, Elizabeth
author_facet Naicy, Thomas
Venkatachalapathy, R.T.
Aravindakshan, T.V.
Kurian, Elizabeth
author_sort Naicy, Thomas
collection PubMed
description The Insulin-like Growth Factor 1 (IGF1) gene is a member of somatotropic axis and plays a key role in proliferation of cells, mitosis, myogenesis, meiosis, differentiation in foetal development and post natal growth. The objectives of this study were to verify the single nucleotide polymorphisms (SNPs) in IGF1 gene and their association with growth traits in two indigenous native goat genetic groups of Kerala, viz., Malabari and Attappady Black. A total of 277 goats were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the restriction enzyme Cac8I. One SNP, A224G was detected in the 5′ non-coding region of the IGF1 gene, and accordingly two genotypes were revealed, GG and AG. This SNP was significantly associated with growth traits in Attappady Black goats, which is maintained as meat breed in Kerala. Results from this study demonstrated higher performance of GG animals for growth traits. The association of IGF1 gene with these traits emphasizes the importance of caprine IGF1 as a candidate gene for growth traits in goat breeding.
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spelling pubmed-62965962019-01-15 Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats Naicy, Thomas Venkatachalapathy, R.T. Aravindakshan, T.V. Kurian, Elizabeth J Genet Eng Biotechnol I : Animal Biotechnology The Insulin-like Growth Factor 1 (IGF1) gene is a member of somatotropic axis and plays a key role in proliferation of cells, mitosis, myogenesis, meiosis, differentiation in foetal development and post natal growth. The objectives of this study were to verify the single nucleotide polymorphisms (SNPs) in IGF1 gene and their association with growth traits in two indigenous native goat genetic groups of Kerala, viz., Malabari and Attappady Black. A total of 277 goats were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the restriction enzyme Cac8I. One SNP, A224G was detected in the 5′ non-coding region of the IGF1 gene, and accordingly two genotypes were revealed, GG and AG. This SNP was significantly associated with growth traits in Attappady Black goats, which is maintained as meat breed in Kerala. Results from this study demonstrated higher performance of GG animals for growth traits. The association of IGF1 gene with these traits emphasizes the importance of caprine IGF1 as a candidate gene for growth traits in goat breeding. Academy of Scientific Research and Technology, Egypt 2017-06 2017-04-21 /pmc/articles/PMC6296596/ /pubmed/30647636 http://dx.doi.org/10.1016/j.jgeb.2017.04.002 Text en © 2017 Production and hosting by Elsevier B.V. on behalf of Academy of Scientific Research & Technology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle I : Animal Biotechnology
Naicy, Thomas
Venkatachalapathy, R.T.
Aravindakshan, T.V.
Kurian, Elizabeth
Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title_full Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title_fullStr Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title_full_unstemmed Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title_short Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats
title_sort association of a cac8i polymorphism in the igf1 gene with growth traits in indian goats
topic I : Animal Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296596/
https://www.ncbi.nlm.nih.gov/pubmed/30647636
http://dx.doi.org/10.1016/j.jgeb.2017.04.002
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