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Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes

Human mini-brains (MB) are cerebral organoids that recapitulate in part the complexity of the human brain in a unique three-dimensional in vitro model, yielding discrete brain regions reminiscent of the cerebral cortex. Specific proteins linked to neurodegenerative disorders are physiologically expr...

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Detalles Bibliográficos
Autores principales:	Pavoni, Serena, Jarray, Rafika, Nassor, Ferid, Guyot, Anne-Cécile, Cottin, Steve, Rontard, Jessica, Mikol, Jacqueline, Mabondzo, Aloïse, Deslys, Jean-Philippe, Yates, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296660/ https://www.ncbi.nlm.nih.gov/pubmed/30557391 http://dx.doi.org/10.1371/journal.pone.0209150

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