Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor

Cultured cells easily develop resistance to kinesin-5 inhibitors (K5Is) often by overexpressing a related motor protein, kinesin-12/KIF15, or by acquiring mutations in the N-terminal motor domain of kinesin-5/KIF11 itself. We aimed to identify novel mechanisms responsible for resistance to S-trityl...

Descripción completa

Detalles Bibliográficos
Autores principales: Saeki, Eri, Yasuhira, Shinji, Shibazaki, Masahiko, Tada, Hiroshi, Doita, Minoru, Masuda, Tomoyuki, Maesawa, Chihaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296710/
https://www.ncbi.nlm.nih.gov/pubmed/30557316
http://dx.doi.org/10.1371/journal.pone.0209296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296710/
https://www.ncbi.nlm.nih.gov/pubmed/30557316
http://dx.doi.org/10.1371/journal.pone.0209296

Ejemplares similares