TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

The aberrant expression of squamous lineage markers in pancreatic ductal adenocarcinoma (PDA) has been correlated with poor clinical outcomes. However, the functional role of this putative transdifferentiation event in PDA pathogenesis remains unclear. Here, we show that expression of the transcript...

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Detalles Bibliográficos
Autores principales: Somerville, Tim D.D., Xu, Yali, Miyabayashi, Koji, Tiriac, Hervé, Cleary, Cristian R., Maia-Silva, Diogo, Milazzo, Joseph P., Tuveson, David A., Vakoc, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
https://www.ncbi.nlm.nih.gov/pubmed/30428345
http://dx.doi.org/10.1016/j.celrep.2018.10.051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296757/
https://www.ncbi.nlm.nih.gov/pubmed/30428345
http://dx.doi.org/10.1016/j.celrep.2018.10.051

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