The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs

Viral infections trigger the innate immune system to produce interferons (IFNs), which play important role in host antiviral responses. Co-evolution of viruses with their hosts has favored development of various strategies to evade the effects of IFNs, enabling viruses to survive inside host cells....

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Autores principales: Wang, Yining, Ma, Lina, Stipkovits, Laszlo, Szathmary, Susan, Li, Xuerui, Liu, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297142/
https://www.ncbi.nlm.nih.gov/pubmed/30619109
http://dx.doi.org/10.3389/fmicb.2018.02943
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author Wang, Yining
Ma, Lina
Stipkovits, Laszlo
Szathmary, Susan
Li, Xuerui
Liu, Yongsheng
author_facet Wang, Yining
Ma, Lina
Stipkovits, Laszlo
Szathmary, Susan
Li, Xuerui
Liu, Yongsheng
author_sort Wang, Yining
collection PubMed
description Viral infections trigger the innate immune system to produce interferons (IFNs), which play important role in host antiviral responses. Co-evolution of viruses with their hosts has favored development of various strategies to evade the effects of IFNs, enabling viruses to survive inside host cells. One such strategy involves inhibition of IFN signaling pathways by non-structural proteins. In this review, we provide a brief overview of host signaling pathways inducing IFN production and their suppression by picornavirus non-structural proteins. Using this strategy, picornaviruses can evade the host immune response and replicate inside host cells.
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spelling pubmed-62971422019-01-07 The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs Wang, Yining Ma, Lina Stipkovits, Laszlo Szathmary, Susan Li, Xuerui Liu, Yongsheng Front Microbiol Microbiology Viral infections trigger the innate immune system to produce interferons (IFNs), which play important role in host antiviral responses. Co-evolution of viruses with their hosts has favored development of various strategies to evade the effects of IFNs, enabling viruses to survive inside host cells. One such strategy involves inhibition of IFN signaling pathways by non-structural proteins. In this review, we provide a brief overview of host signaling pathways inducing IFN production and their suppression by picornavirus non-structural proteins. Using this strategy, picornaviruses can evade the host immune response and replicate inside host cells. Frontiers Media S.A. 2018-12-11 /pmc/articles/PMC6297142/ /pubmed/30619109 http://dx.doi.org/10.3389/fmicb.2018.02943 Text en Copyright © 2018 Wang, Ma, Stipkovits, Szathmary, Li and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Yining
Ma, Lina
Stipkovits, Laszlo
Szathmary, Susan
Li, Xuerui
Liu, Yongsheng
The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title_full The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title_fullStr The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title_full_unstemmed The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title_short The Strategy of Picornavirus Evading Host Antiviral Responses: Non-structural Proteins Suppress the Production of IFNs
title_sort strategy of picornavirus evading host antiviral responses: non-structural proteins suppress the production of ifns
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297142/
https://www.ncbi.nlm.nih.gov/pubmed/30619109
http://dx.doi.org/10.3389/fmicb.2018.02943
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