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Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy

Introduction: Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures of focal onset. ESL owns a good profile in terms of efficacy and tolerability, but its effects on EEG activity and connectivity are unknown. The purpose...

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Autores principales: Pellegrino, Giovanni, Mecarelli, Oriano, Pulitano, Patrizia, Tombini, Mario, Ricci, Lorenzo, Lanzone, Jacopo, Brienza, Marianna, Davassi, Chiara, Di Lazzaro, Vincenzo, Assenza, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297144/
https://www.ncbi.nlm.nih.gov/pubmed/30619030
http://dx.doi.org/10.3389/fneur.2018.01054
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author Pellegrino, Giovanni
Mecarelli, Oriano
Pulitano, Patrizia
Tombini, Mario
Ricci, Lorenzo
Lanzone, Jacopo
Brienza, Marianna
Davassi, Chiara
Di Lazzaro, Vincenzo
Assenza, Giovanni
author_facet Pellegrino, Giovanni
Mecarelli, Oriano
Pulitano, Patrizia
Tombini, Mario
Ricci, Lorenzo
Lanzone, Jacopo
Brienza, Marianna
Davassi, Chiara
Di Lazzaro, Vincenzo
Assenza, Giovanni
author_sort Pellegrino, Giovanni
collection PubMed
description Introduction: Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures of focal onset. ESL owns a good profile in terms of efficacy and tolerability, but its effects on EEG activity and connectivity are unknown. The purpose of this study was to investigate EEG activity and connectivity changes after ESL treatment in persons with focal epilepsy (PFE). Material and Methods: We performed a multicentre, longitudinal, retrospective, quantitative EEG study on a population of 22 PFE, and a group of 40 controls. We investigated the ESL-related changes of EEG power spectral activity and global connectivity [phase locking value (PLV), amplitude envelope correlation (AEC) and amplitude envelope correlation of orthogonalized signals (Ortho-AEC)] for standard frequency bands (delta to gamma). Seizure frequency was evaluated to assess ESL efficacy in our cohort. Results: ESL significantly enhanced both global power spectral density and connectivity for all frequency bands, similarly for all connectivity measures. When compared to the control group, Post-ESL power was significantly higher in theta and gamma band. Pre-ESL connectivity values were significantly lower than control for all frequency bands. Post-ESL connectivity increased and the gap between the two groups was no longer significant. ESL induced a 52.7 ± 41.1% reduction of seizure frequency, with 55% of clinical responders (reduction of seizures ≥50%). Discussion: ESL therapy induces significant enhancement of brain activity and connectivity. Post-ESL connectivity profile of epilepsy patients was similar to the one of healthy controls.
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spelling pubmed-62971442019-01-07 Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy Pellegrino, Giovanni Mecarelli, Oriano Pulitano, Patrizia Tombini, Mario Ricci, Lorenzo Lanzone, Jacopo Brienza, Marianna Davassi, Chiara Di Lazzaro, Vincenzo Assenza, Giovanni Front Neurol Neurology Introduction: Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures of focal onset. ESL owns a good profile in terms of efficacy and tolerability, but its effects on EEG activity and connectivity are unknown. The purpose of this study was to investigate EEG activity and connectivity changes after ESL treatment in persons with focal epilepsy (PFE). Material and Methods: We performed a multicentre, longitudinal, retrospective, quantitative EEG study on a population of 22 PFE, and a group of 40 controls. We investigated the ESL-related changes of EEG power spectral activity and global connectivity [phase locking value (PLV), amplitude envelope correlation (AEC) and amplitude envelope correlation of orthogonalized signals (Ortho-AEC)] for standard frequency bands (delta to gamma). Seizure frequency was evaluated to assess ESL efficacy in our cohort. Results: ESL significantly enhanced both global power spectral density and connectivity for all frequency bands, similarly for all connectivity measures. When compared to the control group, Post-ESL power was significantly higher in theta and gamma band. Pre-ESL connectivity values were significantly lower than control for all frequency bands. Post-ESL connectivity increased and the gap between the two groups was no longer significant. ESL induced a 52.7 ± 41.1% reduction of seizure frequency, with 55% of clinical responders (reduction of seizures ≥50%). Discussion: ESL therapy induces significant enhancement of brain activity and connectivity. Post-ESL connectivity profile of epilepsy patients was similar to the one of healthy controls. Frontiers Media S.A. 2018-12-11 /pmc/articles/PMC6297144/ /pubmed/30619030 http://dx.doi.org/10.3389/fneur.2018.01054 Text en Copyright © 2018 Pellegrino, Mecarelli, Pulitano, Tombini, Ricci, Lanzone, Brienza, Davassi, Di Lazzaro and Assenza. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Pellegrino, Giovanni
Mecarelli, Oriano
Pulitano, Patrizia
Tombini, Mario
Ricci, Lorenzo
Lanzone, Jacopo
Brienza, Marianna
Davassi, Chiara
Di Lazzaro, Vincenzo
Assenza, Giovanni
Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title_full Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title_fullStr Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title_full_unstemmed Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title_short Eslicarbazepine Acetate Modulates EEG Activity and Connectivity in Focal Epilepsy
title_sort eslicarbazepine acetate modulates eeg activity and connectivity in focal epilepsy
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297144/
https://www.ncbi.nlm.nih.gov/pubmed/30619030
http://dx.doi.org/10.3389/fneur.2018.01054
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