Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms

Many proteins involved in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS) are remarkably similar to proteins that form prions in the yeast Saccharomyces cerevisiae. These ALS-associated proteins are not orthologs of yeast prion proteins, but are similar in having long, intrinsically...

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Detalles Bibliográficos
Autores principales: Monahan, Zachary T., Rhoads, Shannon N., Yee, Debra S., Shewmaker, Frank P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297178/
https://www.ncbi.nlm.nih.gov/pubmed/30618605
http://dx.doi.org/10.3389/fnmol.2018.00453

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