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A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI

Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated. We herein report a possible patient with thiamine-deficiency neuropathy exhibiting muscle weakness and myalgia in lower li...

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Autores principales: Murate, Kenichiro, Mizutani, Yasuaki, Maeda, Toshiki, Nagao, Ryunosuke, Kikuchi, Kouichi, Shima, Sayuri, Niimi, Yoshiki, Ueda, Akihiro, Ito, Shinji, Mutoh, Tatsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297209/
https://www.ncbi.nlm.nih.gov/pubmed/30619043
http://dx.doi.org/10.3389/fneur.2018.01083
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author Murate, Kenichiro
Mizutani, Yasuaki
Maeda, Toshiki
Nagao, Ryunosuke
Kikuchi, Kouichi
Shima, Sayuri
Niimi, Yoshiki
Ueda, Akihiro
Ito, Shinji
Mutoh, Tatsuro
author_facet Murate, Kenichiro
Mizutani, Yasuaki
Maeda, Toshiki
Nagao, Ryunosuke
Kikuchi, Kouichi
Shima, Sayuri
Niimi, Yoshiki
Ueda, Akihiro
Ito, Shinji
Mutoh, Tatsuro
author_sort Murate, Kenichiro
collection PubMed
description Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated. We herein report a possible patient with thiamine-deficiency neuropathy exhibiting muscle weakness and myalgia in lower limbs. The patient exhibited abnormal muscle signal intensities on MRI corresponding to the site of myalgia. After thiamine replacement therapy, rapid improvement of clinical symptoms and abnormal MRI findings were observed. Muscle MRI findings in this case implicated the possible mechanism of myalgia observed in patients with thiamine deficiency neuropathy.
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spelling pubmed-62972092019-01-07 A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI Murate, Kenichiro Mizutani, Yasuaki Maeda, Toshiki Nagao, Ryunosuke Kikuchi, Kouichi Shima, Sayuri Niimi, Yoshiki Ueda, Akihiro Ito, Shinji Mutoh, Tatsuro Front Neurol Neurology Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated. We herein report a possible patient with thiamine-deficiency neuropathy exhibiting muscle weakness and myalgia in lower limbs. The patient exhibited abnormal muscle signal intensities on MRI corresponding to the site of myalgia. After thiamine replacement therapy, rapid improvement of clinical symptoms and abnormal MRI findings were observed. Muscle MRI findings in this case implicated the possible mechanism of myalgia observed in patients with thiamine deficiency neuropathy. Frontiers Media S.A. 2018-12-11 /pmc/articles/PMC6297209/ /pubmed/30619043 http://dx.doi.org/10.3389/fneur.2018.01083 Text en Copyright © 2018 Murate, Mizutani, Maeda, Nagao, Kikuchi, Shima, Niimi, Ueda, Ito and Mutoh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Murate, Kenichiro
Mizutani, Yasuaki
Maeda, Toshiki
Nagao, Ryunosuke
Kikuchi, Kouichi
Shima, Sayuri
Niimi, Yoshiki
Ueda, Akihiro
Ito, Shinji
Mutoh, Tatsuro
A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title_full A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title_fullStr A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title_full_unstemmed A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title_short A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
title_sort patient with thiamine deficiency exhibiting muscle edema suggested by mri
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297209/
https://www.ncbi.nlm.nih.gov/pubmed/30619043
http://dx.doi.org/10.3389/fneur.2018.01083
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