Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

Large copy number variants (CNVs) in the human genome are strongly associated with common neurodevelopmental, neuropsychiatric disorders such as schizophrenia and autism. Here we report on the epigenomic effects of the prominent large deletion CNVs on chromosome 22q11.2 and on chromosome 1q21.1. We...

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Detalles Bibliográficos
Autores principales: Zhang, Xianglong, Zhang, Ying, Zhu, Xiaowei, Purmann, Carolin, Haney, Michael S., Ward, Thomas, Khechaduri, Arineh, Yao, Jie, Weissman, Sherman M., Urban, Alexander E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297223/
https://www.ncbi.nlm.nih.gov/pubmed/30559385
http://dx.doi.org/10.1038/s41467-018-07766-x

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