Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear. Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α (IRE1α), links...

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Detalles Bibliográficos
Autores principales: Govindarajan, Srinath, Gaublomme, Djoere, Van der Cruyssen, Renée, Verheugen, Eveline, Van Gassen, Sofie, Saeys, Yvan, Tavernier, Simon, Iwawaki, Takao, Bloch, Yehudi, Savvides, Savvas. N., Lambrecht, Bart N., Janssens, Sophie, Elewaut, Dirk, Drennan, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297233/
https://www.ncbi.nlm.nih.gov/pubmed/30559399
http://dx.doi.org/10.1038/s41467-018-07758-x

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