c-Jun N-terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats

Early brain injury (EBI)-induced neuronal apoptosis is primarily responsible for the subsequent complications of aneurysmal subarachnoid hemorrhage (aSAH), which may increase the risk of mortality in patients with aSAH. c-Jun N-terminal kinase (JNK) has been demonstrated to be a promoter of EBI-indu...

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Autores principales: Ling, Geng-Qiang, Li, Xian-Feng, Lei, Xu-Hui, Wang, Zhen-Yu, Ma, Dong-Ying, Wang, Yue-Na, Ye, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297759/
https://www.ncbi.nlm.nih.gov/pubmed/30431087
http://dx.doi.org/10.3892/mmr.2018.9640

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