Cargando…

MEK inhibition prevents TGF-β1-induced myofibroblast transdifferentiation in human tenon fibroblasts

Subconjunctival fibrosis represents the primary cause of postoperative failure of trabeculectomy, and at present there is a lack of effective intervention strategies. The present study aimed to investigate the effect of the mitogen-activated protein kinase kinase (MEK) inhibitor U0126 on human tenon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wen, Jiamin, Lin, Xianchai, Gao, Wuyou, Qu, Bo, Ling, Yunlan, Liu, Rongjiao, Yu, Minbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297771/ https://www.ncbi.nlm.nih.gov/pubmed/30483803 http://dx.doi.org/10.3892/mmr.2018.9673

Ejemplares similares

Nintedanib inhibits TGF-β-induced myofibroblast transdifferentiation in human Tenon’s fibroblasts
por: Lin, Xianchai, et al.
Publicado: (2018)

TGF-β-induced interleukin-6 participates in transdifferentiation of human Tenon’s fibroblasts to myofibroblasts
por: Seong, Gong Je, et al.
Publicado: (2009)

The Role of Focal Adhesion Kinase in the TGF-β-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
por: Hong, Samin, et al.
Publicado: (2012)

Role of Heat Shock Protein 47 in Transdifferentiation of Human Tenon's Fibroblasts to Myofibroblasts
por: Hong, Samin, et al.
Publicado: (2012)

Rasch analysis of the hospital anxiety and depression scale among Chinese cataract patients
por: Lin, Xianchai, et al.
Publicado: (2017)

Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon’s capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10
por: Yamashiro, Chiemi, et al.
Publicado: (2021)

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
por: Zhang, Lijun, et al.
Publicado: (2015)

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts
por: Razdan, Neetu, et al.
Publicado: (2018)

miR-216a exacerbates TGF-β-induced myofibroblast transdifferentiation via PTEN/AKT signaling
por: Qu, Chuan, et al.
Publicado: (2019)

Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Effects of ranibizumab on TGF-β1 and TGF-β2 production by human Tenon’s fibroblasts: An in vitro study
por: Noh, Siti Munirah Md, et al.
Publicado: (2015)

Retraction: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy
por: Wang, Xiaoyuan, et al.
Publicado: (2021)

Preoperative Expectations and Postoperative Outcomes of Visual Functioning among Cataract Patients in Urban Southern China
por: Chen, Ziyan, et al.
Publicado: (2017)

YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy
por: Jin, Bo, et al.
Publicado: (2018)

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery
por: Cheng, Wen-Sheng, et al.
Publicado: (2020)

Rosiglitazone Inhibits TGF-β 1 Induced Activation of Human Tenon Fibroblasts via p38 Signal Pathway
por: Luo, Yong-Heng, et al.
Publicado: (2014)

JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
por: Hou, Tzu-Yu, et al.
Publicado: (2021)

Essential role of connective tissue growth factor (CTGF) in transforming growth factor-β1 (TGF-β1)-induced myofibroblast transdifferentiation from Graves’ orbital fibroblasts
por: Tsai, Chieh-Chih, et al.
Publicado: (2018)

Silencing of ILK attenuates the abnormal proliferation and migration of human Tenon's capsule fibroblasts induced by TGF-β2
por: Xing, Yao, et al.
Publicado: (2016)

Slow Interstitial Fluid Flow Activates TGF-β Signaling and Drives Fibrotic Responses in Human Tenon Fibroblasts
por: Wiedenmann, Cornelius Jakob, et al.
Publicado: (2023)

Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways
por: Xu, Hui, et al.
Publicado: (2022)

Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon’s fibroblasts
por: Hong, Samin, et al.
Publicado: (2015)

Electrical Stimulation Promotes Wound Healing by Enhancing Dermal Fibroblast Activity and Promoting Myofibroblast Transdifferentiation
por: Rouabhia, Mahmoud, et al.
Publicado: (2013)

Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1
por: Chang, Yu-Chao, et al.
Publicado: (2014)

Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms
por: Kim, Jung-Yeon, et al.
Publicado: (2020)

Swimming Exercise Prevents Fibrogenesis in Chronic Kidney Disease by Inhibiting the Myofibroblast Transdifferentiation
por: Peng, Chiung-Chi, et al.
Publicado: (2012)

Transcriptomic changes during TGF-β-mediated differentiation of airway fibroblasts to myofibroblasts
por: Walker, Erin Joanne, et al.
Publicado: (2019)

The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
por: Yan, Qiong, et al.
Publicado: (2018)

Zebularine suppresses TGF-beta-induced lens epithelial cell–myofibroblast transdifferentiation by inhibiting MeCP2
por: Zhou, Peng, et al.
Publicado: (2011)

SPARC is expressed in scars of the Tenon’s capsule and mediates scarring properties of human Tenon’s fibroblasts in vitro
por: Fuchshofer, Rudolf, et al.
Publicado: (2011)

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation
por: Ijaz, Talha, et al.
Publicado: (2017)

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21
por: Liu, Ying, et al.
Publicado: (2016)

Inhibition of Pirfenidone on TGF-beta2 Induced Proliferation, Migration and Epithlial-Mesenchymal Transition of Human Lens Epithelial Cells Line SRA01/04
por: Yang, Yangfan, et al.
Publicado: (2013)

MicroRNA-375 prevents TGF-β-dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway
por: Zhang, Xinghua, et al.
Publicado: (2020)

A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
por: Li, Zhang, et al.
Publicado: (2011)

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2016)

Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys
por: Kanno, Claudia Misue, et al.
Publicado: (2018)

Sphingosine kinase 1 is required for TGF-β mediated fibroblast-to-myofibroblast differentiation in ovarian cancer
por: Beach, Jessica A., et al.
Publicado: (2015)

Fenofibrate inhibits TGF‐β‐induced myofibroblast differentiation and activation in human lung fibroblasts in vitro
por: Kikuchi, Ryota, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l2kpnjvpmiq2de6ft2oa7ngaei