Genetic Mutations in the S-loop of Human Glutathione Synthetase: Links Between Substrate Binding, Active Site Structure and Allostery

The second step in the biosynthesis of the cellular antioxidant glutathione (GSH) is catalyzed by human glutathione synthetase (hGS), a negatively cooperative homodimer. Patients with mutations in hGS have been reported to exhibit a range of symptoms from hemolytic anemia and metabolic acidosis to n...

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Detalles Bibliográficos
Autores principales: Ingle, Brandall L., Shrestha, Bisesh, De Jesus, Margarita C., Conrad-Webb, Heather M., Anderson, Mary E., Cundari, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297838/
https://www.ncbi.nlm.nih.gov/pubmed/30581542
http://dx.doi.org/10.1016/j.csbj.2018.11.008

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