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The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study

Persons with multiple sclerosis (pwMS) experience declines in physical and cognitive abilities and are challenged by dual-tasks. Dual-tasking causes a drop in performance, or what is known as dual-task cost (DTC). This study examined DTC of walking speed (WS) and cognitive performance (CP) in pwMS a...

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Autores principales: Saleh, Soha, Sandroff, Brian M., Vitiello, Tyler, Owoeye, Oyindamola, Hoxha, Armand, Hake, Patrick, Goverover, Yael, Wylie, Glenn, Yue, Guang, DeLuca, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297844/
https://www.ncbi.nlm.nih.gov/pubmed/30618658
http://dx.doi.org/10.3389/fnbeh.2018.00296
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author Saleh, Soha
Sandroff, Brian M.
Vitiello, Tyler
Owoeye, Oyindamola
Hoxha, Armand
Hake, Patrick
Goverover, Yael
Wylie, Glenn
Yue, Guang
DeLuca, John
author_facet Saleh, Soha
Sandroff, Brian M.
Vitiello, Tyler
Owoeye, Oyindamola
Hoxha, Armand
Hake, Patrick
Goverover, Yael
Wylie, Glenn
Yue, Guang
DeLuca, John
author_sort Saleh, Soha
collection PubMed
description Persons with multiple sclerosis (pwMS) experience declines in physical and cognitive abilities and are challenged by dual-tasks. Dual-tasking causes a drop in performance, or what is known as dual-task cost (DTC). This study examined DTC of walking speed (WS) and cognitive performance (CP) in pwMS and healthy controls (HCs) and the effect of dual-tasking on cortical activation of bilateral premotor cortices (PMC) and bilateral supplementary motor area (SMA). Fourteen pwMS and 14 HCs performed three experimental tasks: (1) single cognitive task while standing (SingCog); (2) single walking task (SingWalk); and (3) dual-task (DualT) that included concurrent performance of the SingCog and SingWalk. Six trials were collected for each condition and included measures of cortical activation, WS and CP. WS of pwMS was significantly lower than HC, but neuropsychological (NP) measures were not significantly different. pwMS and HC groups had similar DTC of WS, while DTC of CP was only significant in the MS group; processing speed and visual memory predicted 55% of this DTC. DualT vs. SingWalk recruited more right-PMC activation only in HCs and was associated with better processing speed. DualT vs. SingCog recruited more right-PMC activation and bilateral-SMA activation in both HC and pwMS. Lower baseline WS and worse processing speed measures in pwMS predicted higher recruitment of right-SMA (rSMA) activation suggesting maladaptive recruitment. Lack of significant difference in NP measures between groups does not rule out the influence of cognitive factors on dual-tasking performance and cortical activations in pwMS, which might have a negative impact on quality of life.
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spelling pubmed-62978442019-01-07 The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study Saleh, Soha Sandroff, Brian M. Vitiello, Tyler Owoeye, Oyindamola Hoxha, Armand Hake, Patrick Goverover, Yael Wylie, Glenn Yue, Guang DeLuca, John Front Behav Neurosci Neuroscience Persons with multiple sclerosis (pwMS) experience declines in physical and cognitive abilities and are challenged by dual-tasks. Dual-tasking causes a drop in performance, or what is known as dual-task cost (DTC). This study examined DTC of walking speed (WS) and cognitive performance (CP) in pwMS and healthy controls (HCs) and the effect of dual-tasking on cortical activation of bilateral premotor cortices (PMC) and bilateral supplementary motor area (SMA). Fourteen pwMS and 14 HCs performed three experimental tasks: (1) single cognitive task while standing (SingCog); (2) single walking task (SingWalk); and (3) dual-task (DualT) that included concurrent performance of the SingCog and SingWalk. Six trials were collected for each condition and included measures of cortical activation, WS and CP. WS of pwMS was significantly lower than HC, but neuropsychological (NP) measures were not significantly different. pwMS and HC groups had similar DTC of WS, while DTC of CP was only significant in the MS group; processing speed and visual memory predicted 55% of this DTC. DualT vs. SingWalk recruited more right-PMC activation only in HCs and was associated with better processing speed. DualT vs. SingCog recruited more right-PMC activation and bilateral-SMA activation in both HC and pwMS. Lower baseline WS and worse processing speed measures in pwMS predicted higher recruitment of right-SMA (rSMA) activation suggesting maladaptive recruitment. Lack of significant difference in NP measures between groups does not rule out the influence of cognitive factors on dual-tasking performance and cortical activations in pwMS, which might have a negative impact on quality of life. Frontiers Media S.A. 2018-12-11 /pmc/articles/PMC6297844/ /pubmed/30618658 http://dx.doi.org/10.3389/fnbeh.2018.00296 Text en Copyright © 2018 Saleh, Sandroff, Vitiello, Owoeye, Hoxha, Hake, Goverover, Wylie, Yue and DeLuca. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Saleh, Soha
Sandroff, Brian M.
Vitiello, Tyler
Owoeye, Oyindamola
Hoxha, Armand
Hake, Patrick
Goverover, Yael
Wylie, Glenn
Yue, Guang
DeLuca, John
The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title_full The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title_fullStr The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title_full_unstemmed The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title_short The Role of Premotor Areas in Dual Tasking in Healthy Controls and Persons With Multiple Sclerosis: An fNIRS Imaging Study
title_sort role of premotor areas in dual tasking in healthy controls and persons with multiple sclerosis: an fnirs imaging study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297844/
https://www.ncbi.nlm.nih.gov/pubmed/30618658
http://dx.doi.org/10.3389/fnbeh.2018.00296
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