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Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study

BACKGROUND: The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR−) male breast cancer. METHODS: Using the US National Cancer Institute’s Surveillance, Epidemiology, and End Results database, we compar...

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Autores principales: Wei, Jin-Li, Zhang, Jia-Xin, Fu, De-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297954/
https://www.ncbi.nlm.nih.gov/pubmed/30558615
http://dx.doi.org/10.1186/s12957-018-1539-7
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author Wei, Jin-Li
Zhang, Jia-Xin
Fu, De-Yuan
author_facet Wei, Jin-Li
Zhang, Jia-Xin
Fu, De-Yuan
author_sort Wei, Jin-Li
collection PubMed
description BACKGROUND: The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR−) male breast cancer. METHODS: Using the US National Cancer Institute’s Surveillance, Epidemiology, and End Results database, we compared the demographics, clinical characteristics, and outcome of estrogen receptor-positive/progesterone receptor-positive (ER+/PR+) patients with ER+/PR− male breast cancer patients from 1990 to 2010. Two thousand three hundred twenty-two patients with ER+/PR+ tumors and 355 patients with ER+/PR− tumors were included in our study. RESULTS: ER+/PR− patients were younger (P = 0.008) and more likely to be African American (P < 0.001) while presented with higher histological grade (P < 0.001), larger tumor size (P = 0.010), and more invasion to the lymph nodes (P = 0.034) and distant sites (P < 0.001), thus later stage (P = 0.001). Despite higher chance of receiving chemotherapy (51.0% vs 36.5%, P < 0.001), ER+/PR− patients experienced significantly worse breast cancer-specific survival (BSCC) (P < 0.001) and shorter overall survival (OS) (P = 0.003). Multivariate Cox model confirmed that tumor size, lymph node invasion, metastasis, and surgery were independent prognostic factors of both BSCC and OS for ER+/PR− male breast cancer. Age at diagnosis and chemotherapy were significantly associated with OS but not with BSCC. CONCLUSION: ER+/PR− male breast cancer was more aggressive and experienced shorter survival than ER+/PR+ patients. The prognosis was mainly associated with tumor size, lymph node invasion, metastasis, and surgery.
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spelling pubmed-62979542018-12-19 Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study Wei, Jin-Li Zhang, Jia-Xin Fu, De-Yuan World J Surg Oncol Research BACKGROUND: The aim of this study was to explore the characteristics and prognostic information of estrogen receptor-positive/progesterone receptor-negative (ER+/PR−) male breast cancer. METHODS: Using the US National Cancer Institute’s Surveillance, Epidemiology, and End Results database, we compared the demographics, clinical characteristics, and outcome of estrogen receptor-positive/progesterone receptor-positive (ER+/PR+) patients with ER+/PR− male breast cancer patients from 1990 to 2010. Two thousand three hundred twenty-two patients with ER+/PR+ tumors and 355 patients with ER+/PR− tumors were included in our study. RESULTS: ER+/PR− patients were younger (P = 0.008) and more likely to be African American (P < 0.001) while presented with higher histological grade (P < 0.001), larger tumor size (P = 0.010), and more invasion to the lymph nodes (P = 0.034) and distant sites (P < 0.001), thus later stage (P = 0.001). Despite higher chance of receiving chemotherapy (51.0% vs 36.5%, P < 0.001), ER+/PR− patients experienced significantly worse breast cancer-specific survival (BSCC) (P < 0.001) and shorter overall survival (OS) (P = 0.003). Multivariate Cox model confirmed that tumor size, lymph node invasion, metastasis, and surgery were independent prognostic factors of both BSCC and OS for ER+/PR− male breast cancer. Age at diagnosis and chemotherapy were significantly associated with OS but not with BSCC. CONCLUSION: ER+/PR− male breast cancer was more aggressive and experienced shorter survival than ER+/PR+ patients. The prognosis was mainly associated with tumor size, lymph node invasion, metastasis, and surgery. BioMed Central 2018-12-17 /pmc/articles/PMC6297954/ /pubmed/30558615 http://dx.doi.org/10.1186/s12957-018-1539-7 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wei, Jin-Li
Zhang, Jia-Xin
Fu, De-Yuan
Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title_full Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title_fullStr Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title_full_unstemmed Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title_short Characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
title_sort characterization and prognosis of estrogen receptor-positive/progesterone receptor-negative male breast cancer: a population-based study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297954/
https://www.ncbi.nlm.nih.gov/pubmed/30558615
http://dx.doi.org/10.1186/s12957-018-1539-7
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