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Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs
BACKGROUND: A prospective, randomized, placebo-controlled, blinded clinical study was conducted to determine whether a single dose of midazolam affects the cardiovascular response to surgical manipulation of the ovaries during elective ovariohysterectomy. Thirty-nine client-owned dogs undergoing ele...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297997/ https://www.ncbi.nlm.nih.gov/pubmed/30568789 http://dx.doi.org/10.1186/s13620-018-0136-y |
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author | Kropf, Josephine Hughes, J.M. Lynne |
author_facet | Kropf, Josephine Hughes, J.M. Lynne |
author_sort | Kropf, Josephine |
collection | PubMed |
description | BACKGROUND: A prospective, randomized, placebo-controlled, blinded clinical study was conducted to determine whether a single dose of midazolam affects the cardiovascular response to surgical manipulation of the ovaries during elective ovariohysterectomy. Thirty-nine client-owned dogs undergoing elective ovariohysterectomy were recruited. After scoring cage demeanour, dogs were premedicated with acepromazine (0.03 mg kg(-1)) and pethidine (3 mg kg(-1)) intramuscularly into the quadriceps muscle and 20 min later sedation was scored. Anaesthesia was induced with propofol intravenously (IV) to effect. The study treatment (group M: midazolam (0.25 mg kg(-1)); or group P: placebo (Hartmann’s solution) (0.125 ml kg(-1))) was administered IV before the intra-operative manipulation of the first ovary. Anaesthesia was maintained with isoflurane in oxygen. Morphine (0.3 mg kg(-1) IV) was administered prior to the start of surgery. The vaporizer setting was adjusted according to the depth of anaesthesia. If an end-tidal isoflurane concentration (FE’Iso) above 1.6% was required additional analgesia was provided with fentanyl (2 μg kg(-1)). Dogs received meloxicam (0.2 mg kg(-1) IV) at the end of procedure. Heart rate, mean arterial blood pressure, respiratory rate and end-tidal partial pressure of carbon dioxide as well as FE’Iso were recorded and analysed. RESULTS: A statistical significant difference between groups was detected in FE’Iso, with group M requiring a significantly lower FE’Iso than group P (14.3%) after administration of midazolam. No differences between groups was shown for percentage change in heart rate and mean arterial blood pressure, or end-tidal carbon dioxide and requirement for mechanical ventilation, or rescue analgesia. There was no statistically significant difference in the incidence of complications in group M and P. Group M received significantly more succinylated gelatin solution pre-administration of midazolam than group P, but no differences in fluid administration post-administration of the study treatment (midazolam/placebo) were detected. No statistical significant difference was demonstrated for the use of anticholinergic agents, dobutamine or noradrenaline. CONCLUSION: No significant effect on cardiovascular parameters could be observed with administration of midazolam, but a modest (14.3%) isoflurane-sparing effect was detected. |
format | Online Article Text |
id | pubmed-6297997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62979972018-12-19 Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs Kropf, Josephine Hughes, J.M. Lynne Ir Vet J Research BACKGROUND: A prospective, randomized, placebo-controlled, blinded clinical study was conducted to determine whether a single dose of midazolam affects the cardiovascular response to surgical manipulation of the ovaries during elective ovariohysterectomy. Thirty-nine client-owned dogs undergoing elective ovariohysterectomy were recruited. After scoring cage demeanour, dogs were premedicated with acepromazine (0.03 mg kg(-1)) and pethidine (3 mg kg(-1)) intramuscularly into the quadriceps muscle and 20 min later sedation was scored. Anaesthesia was induced with propofol intravenously (IV) to effect. The study treatment (group M: midazolam (0.25 mg kg(-1)); or group P: placebo (Hartmann’s solution) (0.125 ml kg(-1))) was administered IV before the intra-operative manipulation of the first ovary. Anaesthesia was maintained with isoflurane in oxygen. Morphine (0.3 mg kg(-1) IV) was administered prior to the start of surgery. The vaporizer setting was adjusted according to the depth of anaesthesia. If an end-tidal isoflurane concentration (FE’Iso) above 1.6% was required additional analgesia was provided with fentanyl (2 μg kg(-1)). Dogs received meloxicam (0.2 mg kg(-1) IV) at the end of procedure. Heart rate, mean arterial blood pressure, respiratory rate and end-tidal partial pressure of carbon dioxide as well as FE’Iso were recorded and analysed. RESULTS: A statistical significant difference between groups was detected in FE’Iso, with group M requiring a significantly lower FE’Iso than group P (14.3%) after administration of midazolam. No differences between groups was shown for percentage change in heart rate and mean arterial blood pressure, or end-tidal carbon dioxide and requirement for mechanical ventilation, or rescue analgesia. There was no statistically significant difference in the incidence of complications in group M and P. Group M received significantly more succinylated gelatin solution pre-administration of midazolam than group P, but no differences in fluid administration post-administration of the study treatment (midazolam/placebo) were detected. No statistical significant difference was demonstrated for the use of anticholinergic agents, dobutamine or noradrenaline. CONCLUSION: No significant effect on cardiovascular parameters could be observed with administration of midazolam, but a modest (14.3%) isoflurane-sparing effect was detected. BioMed Central 2018-12-17 /pmc/articles/PMC6297997/ /pubmed/30568789 http://dx.doi.org/10.1186/s13620-018-0136-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Kropf, Josephine Hughes, J.M. Lynne Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title | Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title_full | Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title_fullStr | Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title_full_unstemmed | Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title_short | Effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
title_sort | effects of midazolam on cardiovascular responses and isoflurane requirement during elective ovariohysterectomy in dogs |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297997/ https://www.ncbi.nlm.nih.gov/pubmed/30568789 http://dx.doi.org/10.1186/s13620-018-0136-y |
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