Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

BACKGROUND: Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Pisanu, Maria Elena, Maugeri-Saccà, Marcello, Fattore, Luigi, Bruschini, Sara, De Vitis, Claudia, Tabbì, Eugenio, Bellei, Barbara, Migliano, Emilia, Kovacs, Daniela, Camera, Emanuela, Picardo, Mauro, Jakopin, Ziga, Cippitelli, Claudia, Bartolazzi, Armando, Raffa, Salvatore, Torrisi, Maria Rosaria, Fulciniti, Franco, Ascierto, Paolo A., Ciliberto, Gennaro, Mancini, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298024/
https://www.ncbi.nlm.nih.gov/pubmed/30558661
http://dx.doi.org/10.1186/s13046-018-0989-7

Ejemplares similares

Ejemplares similares