Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

BACKGROUND: The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity. RESULTS:...

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Detalles Bibliográficos
Autores principales: Wu, Ziyun, Senchuk, Megan M., Dues, Dylan J., Johnson, Benjamin K., Cooper, Jason F., Lew, Leira, Machiela, Emily, Schaar, Claire E., DeJonge, Heather, Blackwell, T. Keith, Van Raamsdonk, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298126/
https://www.ncbi.nlm.nih.gov/pubmed/30563508
http://dx.doi.org/10.1186/s12915-018-0615-3

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