Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive immunization, but the immunological mechanisms that drive their development are poorly understood. Structural features of bNAbs indicate that they originate from extensive germinal center (GC) selection, which relie...

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Detalles Bibliográficos
Autores principales: Lofano, Giuseppe, Gorman, Matthew J., Yousif, Ashraf S., Yu, Wen-Han, Fox, Julie M., Dugast, Anne-Sophie, Ackerman, Margaret E., Suscovich, Todd J., Weiner, Joshua, Barouch, Dan, Streeck, Hendrik, Little, Susan, Smith, Davey, Richman, Douglas, Lauffenburger, Douglas, Walker, Bruce D., Diamond, Michael S., Alter, Galit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
HIV
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298214/
https://www.ncbi.nlm.nih.gov/pubmed/30120121
http://dx.doi.org/10.1126/sciimmunol.aat7796

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