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A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutrali...

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Autores principales: Van Quickelberghe, Emmy, De Sutter, Delphine, van Loo, Geert, Eyckerman, Sven, Gevaert, Kris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298254/
https://www.ncbi.nlm.nih.gov/pubmed/30561431
http://dx.doi.org/10.1038/sdata.2018.289
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author Van Quickelberghe, Emmy
De Sutter, Delphine
van Loo, Geert
Eyckerman, Sven
Gevaert, Kris
author_facet Van Quickelberghe, Emmy
De Sutter, Delphine
van Loo, Geert
Eyckerman, Sven
Gevaert, Kris
author_sort Van Quickelberghe, Emmy
collection PubMed
description Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe immune side effects. There is thus an urging need to identify novel targets for pharmaceutical intervention in the NF-κB signaling pathway. Here, we present a protein-protein interaction dataset of the TNFR1-induced signaling pathway. For this, we used Virotrap, a novel method for studying protein complexes without disrupting the cellular integrity, on 12 central proteins controlling NF-κB and cell death signaling, both under resting conditions as well as upon TNF stimulation. Our dataset reveals dynamic interactions in TNFR1-induced NF-κB signaling and identifies both known as well as novel interactors that may help to further unravel the molecular mechanisms steering TNF-induced inflammatory signaling and pathology.
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spelling pubmed-62982542018-12-19 A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway Van Quickelberghe, Emmy De Sutter, Delphine van Loo, Geert Eyckerman, Sven Gevaert, Kris Sci Data Data Descriptor Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe immune side effects. There is thus an urging need to identify novel targets for pharmaceutical intervention in the NF-κB signaling pathway. Here, we present a protein-protein interaction dataset of the TNFR1-induced signaling pathway. For this, we used Virotrap, a novel method for studying protein complexes without disrupting the cellular integrity, on 12 central proteins controlling NF-κB and cell death signaling, both under resting conditions as well as upon TNF stimulation. Our dataset reveals dynamic interactions in TNFR1-induced NF-κB signaling and identifies both known as well as novel interactors that may help to further unravel the molecular mechanisms steering TNF-induced inflammatory signaling and pathology. Nature Publishing Group 2018-12-18 /pmc/articles/PMC6298254/ /pubmed/30561431 http://dx.doi.org/10.1038/sdata.2018.289 Text en Copyright © 2018, The Author(s) http://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.
spellingShingle Data Descriptor
Van Quickelberghe, Emmy
De Sutter, Delphine
van Loo, Geert
Eyckerman, Sven
Gevaert, Kris
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title_full A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title_fullStr A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title_full_unstemmed A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title_short A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
title_sort protein-protein interaction map of the tnf-induced nf-κb signal transduction pathway
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298254/
https://www.ncbi.nlm.nih.gov/pubmed/30561431
http://dx.doi.org/10.1038/sdata.2018.289
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