3-n-butylphthalide exerts neuroprotective effects by enhancing anti-oxidation and attenuating mitochondrial dysfunction in an in vitro model of ischemic stroke

PURPOSE: This study examined whether the neuroprotective drug, 3-n-butylphthalide (NBP), which is used to treat ischemic stroke, prevents mitochondrial dysfunction. MATERIALS AND METHODS: PC12 neuronal cells were pretreated for 24 hours with NBP (10 μmol/L), then exposed to oxygen and glucose depriv...

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Detalles Bibliográficos
Autores principales: Chen, Ningyuan, Zhou, Zhibing, Li, Ji, Li, Bocheng, Feng, Jihua, He, Dan, Luo, Yifeng, Zheng, Xiaowen, Luo, Jiefeng, Zhang, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298396/
https://www.ncbi.nlm.nih.gov/pubmed/30587922
http://dx.doi.org/10.2147/DDDT.S189472

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