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Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1

Tight binding of Gdown1 represses RNA polymerase II (Pol II) function in a manner that is reversed by Mediator, but the structural basis of these processes is unclear. Although Gdown1 is intrinsically disordered, its Pol II interacting domains were localized and shown to occlude TFIIF and TFIIB bind...

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Detalles Bibliográficos
Autores principales:	Jishage, Miki, Yu, Xiaodi, Shi, Yi, Ganesan, Sai J., Chen, Wei-Yi, Sali, Andrej, Chait, Brian T., Asturias, Francisco J., Roeder, Robert G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298426/ https://www.ncbi.nlm.nih.gov/pubmed/30190596 http://dx.doi.org/10.1038/s41594-018-0118-5

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