Cargando…
Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy
BACKGROUND: Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results. METHODS: The study aim was to estimate the biochemical markers’ ability to predict hypertensi...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298456/ https://www.ncbi.nlm.nih.gov/pubmed/30820186 http://dx.doi.org/10.2478/jomb-2018-0001 |
_version_ | 1783381320387264512 |
---|---|
author | Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar |
author_facet | Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar |
author_sort | Belovic, Dušica Kocijančić |
collection | PubMed |
description | BACKGROUND: Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results. METHODS: The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week. RESULTS: Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction. CONCLUSIONS: Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE. |
format | Online Article Text |
id | pubmed-6298456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-62984562019-03-01 Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar J Med Biochem Original Paper BACKGROUND: Gestational hypertension (GH) and pre eclampsia (PE) are the most common gestational complications. Several placental biochemical markers are used to predict GH/PE, but with conflicting results. METHODS: The study aim was to estimate the biochemical markers’ ability to predict hypertensive disorders in pregnancy. On the first ultrasonographic examination, 104 healthy pregnant women were recruited. At the regular pregnancy check-ups, BMI, blood pressure, occurrence of gestational hypertension (early or late onset), preeclampsia, eclampsia and other complications were recorded. Serum concentrations (in multiples of median – MoM) of human chorionic gonadotropin (HCG) and pregnancyassociated plasma protein A (PAPPA) were measured from the 11th to 14th gestational week, while HCG, alpha feto protein (AFP), estriol and inhibin were determined between the 16th and 19th gestational week. RESULTS: Hypertensive disorders throughout pregnancy were diagnosed in 20.2% women. Early-onset GH was registered in 7 and PE in 6 patients, while 14 had late-onset GH and 10 additional women PE. There were no significant differences (p≥0.05) in biochemical markers concentrations between women with and without GH/PE. PAPPA levels in the first and HCG in the second trimester correlated with early and late GH/PE. Moreover, higher AFP concentrations were registered in women with preeclampsia signs/symptoms. According to ROC analysis, AFP>1.05 MoM properly identified 80% of GH/PE cases. Obtained models imply that HCG, PAPPA and AFP should be used for GH/PE prediction. CONCLUSIONS: Biochemical markers HCG, PAPPA and AFP could be useful in predicting gestational hypertension and preeclampsia. However, different markers should be used for early and late onset GH/PE. Sciendo 2019-03-01 /pmc/articles/PMC6298456/ /pubmed/30820186 http://dx.doi.org/10.2478/jomb-2018-0001 Text en © 2019 Dušica Kocijančić Belovic, Snežana Plešinac, Jelena Dotlić, Ana Savić Radojević, Slavica Akšam, Mirjana Marjanović Cvjetićanin, Aleksandar Kocijančić, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Original Paper Belovic, Dušica Kocijančić Plešinac, Snežana Dotlić, Jelena Radojević, Ana Savić Akšam, Slavica Cvjetićanin, Mirjana Marjanović Kocijančić, Aleksandar Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title_full | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title_fullStr | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title_full_unstemmed | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title_short | Biochemical Markers for Prediction of Hypertensive Disorders of Pregnancy |
title_sort | biochemical markers for prediction of hypertensive disorders of pregnancy |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298456/ https://www.ncbi.nlm.nih.gov/pubmed/30820186 http://dx.doi.org/10.2478/jomb-2018-0001 |
work_keys_str_mv | AT belovicdusicakocijancic biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT plesinacsnezana biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT dotlicjelena biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT radojevicanasavic biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT aksamslavica biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT cvjeticaninmirjanamarjanovic biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy AT kocijancicaleksandar biochemicalmarkersforpredictionofhypertensivedisordersofpregnancy |