High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome

PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA...

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Autores principales: Kraszewska-Głomba, Barbara, Myszka, Marta, Krajewska, Magdalena, Szenborn, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298472/
https://www.ncbi.nlm.nih.gov/pubmed/30584411
http://dx.doi.org/10.1515/jomb-2017-0066
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author Kraszewska-Głomba, Barbara
Myszka, Marta
Krajewska, Magdalena
Szenborn, Leszek
author_facet Kraszewska-Głomba, Barbara
Myszka, Marta
Krajewska, Magdalena
Szenborn, Leszek
author_sort Kraszewska-Głomba, Barbara
collection PubMed
description PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis.
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spelling pubmed-62984722018-12-24 High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome Kraszewska-Głomba, Barbara Myszka, Marta Krajewska, Magdalena Szenborn, Leszek J Med Biochem Short Communication PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly contribute to systemic inflammation during PFAPA flares. We carried out anti-mCRP testing (in-house ELISA) in a single-center, prospective cohort of 30 PFAPA patients (12 girls). We found a high prevalence (43.3%) of anti-mCRP antibodies in PFAPA patients during their febrile episodes, which implies the possible involvement of anti-mCRP antibodies in PFAPA pathogenesis. Sciendo 2018-12-01 /pmc/articles/PMC6298472/ /pubmed/30584411 http://dx.doi.org/10.1515/jomb-2017-0066 Text en © 2018 Barbara Kraszewska-Głomba, Marta Myszka, Magdalena Krajewska, Leszek Szenborn published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Short Communication
Kraszewska-Głomba, Barbara
Myszka, Marta
Krajewska, Magdalena
Szenborn, Leszek
High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title_full High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title_fullStr High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title_full_unstemmed High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title_short High Prevalence of Autoantibodies Against Monomeric C Reactive Protein (CRP) in Children with PFAPA Syndrome
title_sort high prevalence of autoantibodies against monomeric c reactive protein (crp) in children with pfapa syndrome
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298472/
https://www.ncbi.nlm.nih.gov/pubmed/30584411
http://dx.doi.org/10.1515/jomb-2017-0066
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