scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?

Posttranscriptional modifications of rRNA occur in the nucleolus where rRNA modification guide RNAs, or snoRNAs, concentrate. On the other hand, scaRNAs, the modification guide RNAs for spliceosomal snRNAs, concentrate in the Cajal body (CB). It is generally assumed, therefore, that snRNAs must accu...

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Detalles Bibliográficos
Autores principales: Deryusheva, Svetlana, Gall, Joseph G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298559/
https://www.ncbi.nlm.nih.gov/pubmed/30301832
http://dx.doi.org/10.1261/rna.068593.118
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author Deryusheva, Svetlana
Gall, Joseph G.
author_facet Deryusheva, Svetlana
Gall, Joseph G.
author_sort Deryusheva, Svetlana
collection PubMed
description Posttranscriptional modifications of rRNA occur in the nucleolus where rRNA modification guide RNAs, or snoRNAs, concentrate. On the other hand, scaRNAs, the modification guide RNAs for spliceosomal snRNAs, concentrate in the Cajal body (CB). It is generally assumed, therefore, that snRNAs must accumulate in CBs to be modified by scaRNAs. Here we demonstrate that the evidence for the latter postulate is not consistent. In the nucleus, scaRNA localization is not limited to CBs. Furthermore, canonical scaRNAs can modify rRNAs. We suggest that the conventional view that scaRNAs function only in the CB needs revision.
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spelling pubmed-62985592020-01-01 scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs? Deryusheva, Svetlana Gall, Joseph G. RNA Letter to the Editor Posttranscriptional modifications of rRNA occur in the nucleolus where rRNA modification guide RNAs, or snoRNAs, concentrate. On the other hand, scaRNAs, the modification guide RNAs for spliceosomal snRNAs, concentrate in the Cajal body (CB). It is generally assumed, therefore, that snRNAs must accumulate in CBs to be modified by scaRNAs. Here we demonstrate that the evidence for the latter postulate is not consistent. In the nucleus, scaRNA localization is not limited to CBs. Furthermore, canonical scaRNAs can modify rRNAs. We suggest that the conventional view that scaRNAs function only in the CB needs revision. Cold Spring Harbor Laboratory Press 2019-01 /pmc/articles/PMC6298559/ /pubmed/30301832 http://dx.doi.org/10.1261/rna.068593.118 Text en © 2019 Deryusheva and Gall; Published by Cold Spring Harbor Laboratory Press for the RNA Society http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Letter to the Editor
Deryusheva, Svetlana
Gall, Joseph G.
scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title_full scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title_fullStr scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title_full_unstemmed scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title_short scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?
title_sort scarnas and snornas: are they limited to specific classes of substrate rnas?
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298559/
https://www.ncbi.nlm.nih.gov/pubmed/30301832
http://dx.doi.org/10.1261/rna.068593.118
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